Zebrafish Fin: Complex Molecular Interactions and Cellular Mechanisms Guiding Regeneration
| Autor: | Ivonne Sehring, Gilbert Weidinger |
|---|---|
| Rok vydání: | 2024 |
| Předmět: |
Cell type
Epidermis (botany) Regeneration (biology) Cell Differentiation Biology Zebrafish Proteins biology.organism_classification General Biochemistry Genetics and Molecular Biology Cell biology Epigenesis Genetic Animals Epigenetics Signal transduction Progenitor cell Blastema Zebrafish Signal Transduction |
| Zdroj: | Cold Spring Harbor perspectives in biology. 14(7) |
| ISSN: | 1943-0264 |
| Popis: | The zebrafish caudal fin has become a popular model to study cellular and molecular mechanisms of regeneration due to its high regenerative capacity, accessibility for experimental manipulations, and relatively simple anatomy. The formation of a regenerative epidermis and blastema are crucial initial events and tightly regulated. Both the regenerative epidermis and the blastema are highly organized structures containing distinct domains, and several signaling pathways regulate the formation and interaction of these domains. Bone is the major tissue regenerated from the progenitor cells of the blastema. Several cellular mechanisms can provide source cells for blastemal (pre-)osteoblasts, including dedifferentiation of differentiated osteoblasts and de novo formation from other cell types, providing intriguing examples of cellular plasticity. In recent years, omics analyses and single-cell approaches have elucidated genetic and epigenetic regulation, increasing our knowledge of the surprisingly complex coordination of various mechanisms to achieve successful restoration of a seemingly simple structure. |
| Databáze: | OpenAIRE |
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