Curcumin as Prospective Anti-Aging Natural Compound: Focus on Brain
| Autor: | Maria Ester La Torre, Raffaella Soleti, Vincenzo Monda, Maria Antonietta Panaro, Giovanni Messina, Chiara Porro, Tarek Benameur |
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| Přispěvatelé: | King Faisal University (KFU), Innate Immunity and Immunotherapy (CRCINA-ÉQUIPE 7), Centre de Recherche en Cancérologie et Immunologie Nantes-Angers (CRCINA), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN)-Centre hospitalier universitaire de Nantes (CHU Nantes)-Centre National de la Recherche Scientifique (CNRS)-Université d'Angers (UA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN)-Centre hospitalier universitaire de Nantes (CHU Nantes)-Centre National de la Recherche Scientifique (CNRS)-Université d'Angers (UA), Università degli studi di Bari Aldo Moro (UNIBA), Università degli Studi di Foggia - University of Foggia, University of the Study of Campania Luigi Vanvitelli, Université d'Angers (UA)-Université de Nantes (UN)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Centre hospitalier universitaire de Nantes (CHU Nantes)-Université d'Angers (UA)-Université de Nantes (UN)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Centre hospitalier universitaire de Nantes (CHU Nantes), Università degli studi di Bari Aldo Moro = University of Bari Aldo Moro (UNIBA), Università degli Studi di Foggia = University of Foggia (Unifg), SOLETI, Raffaella |
| Rok vydání: | 2021 |
| Předmět: |
Aging
antioxidant [SDV.BA] Life Sciences [q-bio]/Animal biology [SDV]Life Sciences [q-bio] Pharmaceutical Science Review Pharmacology medicine.disease_cause Systemic inflammation neuroinflammation Analytical Chemistry chemistry.chemical_compound QD241-441 0302 clinical medicine Drug Discovery Telomerase anti-inflammatory 0303 health sciences biology [SDV.BA]Life Sciences [q-bio]/Animal biology Brain [SDV.SP]Life Sciences [q-bio]/Pharmaceutical sciences 3. Good health [SDV] Life Sciences [q-bio] [SDV.SP] Life Sciences [q-bio]/Pharmaceutical sciences Neuroprotective Agents Chemistry (miscellaneous) 030220 oncology & carcinogenesis Molecular Medicine telomerases medicine.symptom Modern medicine Curcumin medicine.drug_class Inflammation [SDV.BC]Life Sciences [q-bio]/Cellular Biology Anti-inflammatory 03 medical and health sciences medicine Animals Humans Physical and Theoretical Chemistry Curcuma [SDV.BC] Life Sciences [q-bio]/Cellular Biology Neuroinflammation 030304 developmental biology Biological Products business.industry anti-aging Organic Chemistry natural flavonoid biology.organism_classification [SDV.AEN] Life Sciences [q-bio]/Food and Nutrition chemistry business [SDV.AEN]Life Sciences [q-bio]/Food and Nutrition Oxidative stress |
| Zdroj: | Molecules Molecules, MDPI, 2021, 26 (16), pp.4794. ⟨10.3390/molecules26164794⟩ Molecules, 2021, 26 (16), pp.4794. ⟨10.3390/molecules26164794⟩ Molecules, Vol 26, Iss 4794, p 4794 (2021) |
| ISSN: | 1420-3049 |
| DOI: | 10.3390/molecules26164794 |
| Popis: | International audience; The nutrients and their potential benefits are a new field of study in modern medicine for their positive impact on health. Curcumin, the yellow polyphenolic compound extracted from Curcuma longa species, is widely used in traditional Ayurvedic medicine to prevent and contrast many diseases, considering its antioxidant, immunomodulatory, anti-inflammatory, anti-microbial, cardio-protective, nephron-protective, hepato-protective, anti-neoplastic, and anti-rheumatic proprieties. In recent years, the investigations of curcumin have been focused on its application to aging and age-associated diseases. Aging is a physiological process in which there is a decreasing of cellular function due to internal or external stimuli. Oxidative stress is one of the most important causes of aging and age-related diseases. Moreover, many age-related disorders such as cancer, neuroinflammation, and infections are due to a low-grade chronic systemic inflammation. Curcumin acting on different proteins is able to contrast both oxidative stress than inflammation. In the brain, curcumin is able to modulate inflammation induced by microglia. Finally in brain tumors curcumin is able to reduce tumor growth by inhibition of telomerase activity. This review emphasizes the anti-aging role of curcumin focusing on its mechanism to counteract aging in the brain. Moreover, new formulations to increase the bioavailability of curcumin are discussed. |
| Databáze: | OpenAIRE |
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