Cancer cell survival during detachment from the ECM: multiple barriers to tumour progression

Autor:	Kelsey J. Weigel, Zachary T. Schafer, Cassandra L. Buchheit
Rok vydání:	2014
Předmět:	Pathology medicine.medical_specialty Cell Survival Applied Mathematics General Mathematics Cancer Microenvironment Biology Anoikis medicine.disease Extracellular Matrix Metastasis Extracellular matrix Neoplasms Cancer cell medicine Cancer research Humans Viability assay Cell survival
Zdroj:	Nature Reviews Cancer. 14:632-641
ISSN:	1474-1768 1474-175X
DOI:	10.1038/nrc3789
Popis:	Epithelial cells require attachment to the extracellular matrix (ECM) for survival. However, during tumour progression and metastasis, cancerous epithelial cells must adapt to and survive in the absence of ECM. During the past 20 years, several cellular changes, including anoikis, have been shown to regulate cell viability when cells become detached from the ECM. In this Opinion article, we review in detail how cancer cells can overcome or take advantage of these specific processes. Gaining a better understanding of how cancer cells survive during detachment from the ECM will be instrumental in designing chemotherapeutic strategies that aim to eliminate ECM-detached metastatic cells.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::065ec954ccec5099bdf57d0b44306f6c https://doi.org/10.1038/nrc3789 Zobrazit plný text záznamu Plný text ve formátu PDF