Effects of pentobarbitone anaesthesia and atropine on the intravenous glucose tolerance test in normal dogs
| Autor: | R. Rottiers, D. Mattheeuws, A. Vermeulen, J. J. Kaneko |
|---|---|
| Rok vydání: | 1981 |
| Předmět: |
Atropine
Blood Glucose Male medicine.medical_specialty medicine.medical_treatment Dogs Internal medicine Insulin response medicine Animals Insulin Decreased blood flow Small Animals Pentobarbital Plasma glucose business.industry Glucose Tolerance Test Endocrinology medicine.anatomical_structure Intravenous glucose Anesthesia Anesthesia Intravenous Female Intravenous Glucose Tolerance Test business Pancreas medicine.drug |
| Zdroj: | Journal of Small Animal Practice. 22:779-786 |
| ISSN: | 1748-5827 0022-4510 |
| DOI: | 10.1111/j.1748-5827.1981.tb00586.x |
| Popis: | The effect of atropine (0·1 mg/kg b.w. s.c.) and of pentobarbitone anaesthesia (25 mg/kg b.w.) on the plasma glucose clearance and insulin response to an intravenous load of 600 mg and 1,250 mg/kg b.w. glucose was studied in twenty-four normal young Dalmatian dogs (ten male, fourteen female). Neither the rate of disappearance of glucose from the circulation, nor the insulin release following both glucose loads was altered by atropine. However, the disposal of intravenous glucose was significantly (P < 0·01) delayed and the insulin release significantly decreased under pentobarbitone anaesthesia. It is suggested that a decreased blood flow through the pancreas during pentobarbitone anaesthesia is most likely the cause of the decreased insulin release which in turn causes a delayed rate of disappearance of glucose from the circulation. It is therefore concluded that an intravenous glucose tolerance test, as diagnostic procedure, should never be done in anaesthetized dogs. |
| Databáze: | OpenAIRE |
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