Electrophysiological, Morphological, and Morphometric Effects of Aging on Nerve Regeneration in Rats
| Autor: | Kiyonori Harii, Seung-Jae Choi, Fujio Furuya, Kazuki Ueda, Min-Jae Lee |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
Male
Aging Time Factors Motor nerve conduction velocity Neural Conduction Myelin Recovery rate Reaction Time medicine Animals Rats Wistar Evoked potential Axon Nerve repair Electromyography business.industry Regeneration (biology) Age Factors Peroneal Nerve General Medicine Anatomy Axons Nerve Regeneration Rats Electrophysiology medicine.anatomical_structure nervous system Wallerian Degeneration business |
| Zdroj: | Scandinavian Journal of Plastic and Reconstructive Surgery and Hand Surgery. 29:133-140 |
| ISSN: | 0284-4311 |
| DOI: | 10.3109/02844319509034329 |
| Popis: | To investigate the influence of age on the process of nerve regeneration, the right common peroneal nerves of 14 2 month old and 14 10 month old rats were transected and resutured. At four and eight weeks after the nerve repair, the motor nerve conduction velocity (MNCV), latency, and amplitude of the evoked potential from the peroneus longus muscle were measured. The number of regenerated myelinated fibres, axon diameter, axon area, axon circumference, and myelin thickness were also measured. Compared with the control side (left common peroneal nerve and muscle), MNCV, latency, and amplitude showed higher recovery rates (recovery rate (%) = operated/control x 100) in 2 month old rats than in 10 month old rats, particularly at four weeks after the operation. In the morphometric study, axon diameter, axon area, and myelin thickness also recovered more quickly (recovery rate (%) = operated/control x 100) in 2 month old rats, particularly four weeks after the operation. Morphologically, myelin remnants were not found in 2 month old rats eight weeks after the operation, though they remained in 10 month old rats. These studies show that the recovery rate was significantly greater in 2 month old rats than in 10 month old rats. The explanation seems to be the difference in the speed of Wallerian degeneration, axonal regeneration, and myelin regeneration. |
| Databáze: | OpenAIRE |
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