Cardiovascular complications of cancer therapy: diagnosis, pathogenesis, and management
| Autor: | Ann T. Tong, Michael S. Ewer, Christopher J. Champion, Alireza Atef Zafarmand, Jean-Bernard Durand, Joseph Swafford, Edward T.H. Yeh, S. Wamique Yusuf, Daniel J. Lenihan, H. R. Gibbs |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
Drug
medicine.medical_specialty Antimetabolites Antineoplastic Heart disease Cardiovascular Complication medicine.medical_treatment media_common.quotation_subject Biopsy Antineoplastic Agents Risk Factors Physiology (medical) Neoplasms medicine Humans Anthracyclines Intensive care medicine Radiation Injuries Antineoplastic Agents Alkylating media_common Cardiotoxicity Chemotherapy Radiotherapy business.industry food and beverages Cancer Antibodies Monoclonal Heart medicine.disease Surgery Cardiovascular Diseases Toxicity Cytokines Cardiology and Cardiovascular Medicine business Complication Razoxane Pericardium Biomarkers |
| Zdroj: | Circulation. 109(25) |
| ISSN: | 1524-4539 |
| Popis: | The cardiotoxicity of anticancer agents can lead to significant complications that can affect patients being treated for various malignancies. The severity of such toxicity depends on many factors such as the molecular site of action, the immediate and cumulative dose, the method of administration, the presence of any underlying cardiac condition, and the demographics of the patient. Moreover, toxicity can be affected by current or previous treatment with other antineoplastic agents. Cardiotoxic effects can occur immediately during administration of the drug, or they may not manifest themselves until months or years after the patient has been treated. In this article we review commonly used chemotherapy agents, including several recently approved medications, for their propensity to cause cardiotoxicity. Further research will be required to more accurately predict which patients are at risk for developing cardiotoxicity. In addition, management plans, as well as strategies to reduce cardiotoxicity, need to be developed. |
| Databáze: | OpenAIRE |
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