Burden of respiratory syncytial virus hospitalisation among infants born at 32-35 weeks' gestational age in the Northern Hemisphere: Pooled analysis of seven studies
| Autor: | John R. Fullarton, ElizaBeth Grubb, Margaret Sheridan-Pereira, Bosco Paes, Barry Rodgers-Gray, Maarten O Blanken, Xavier Carbonell-Estrany, Evan J. Anderson, Marcello Lanari |
|---|---|
| Přispěvatelé: | Lanari M., Anderson E.J., Sheridan-Pereira M., Carbonell-Estrany X., Paes B., Rodgers-Gray B.S., Fullarton J.R., Grubb E., Blanken M. |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Pediatrics Moderate-to-late preterm infant Epidemiology medicine.medical_treatment Gestational Age Respiratory Syncytial Virus Infections Respiratory syncytial virus Antiviral Agents law.invention Cohort Studies Lower respiratory tract infection 03 medical and health sciences Moderate-to-late preterm infants 0302 clinical medicine Interquartile range law 030225 pediatrics RSV hospitalisation medicine Humans Multicenter Studies as Topic 030212 general & internal medicine Mechanical ventilation Antiviral Agent Respiratory Syncytial Virus Infection Original Paper business.industry Respiratory support Gestational age Infant Length of Stay medicine.disease Intensive care unit Comorbidity Hospitalization Observational Studies as Topic Infectious Diseases Respiratory syncytial viru Respiratory Syncytial Virus Human Breathing Cohort Studie business Human |
| Zdroj: | Epidemiology and Infection |
| Popis: | To provide comprehensive information on the epidemiology and burden of respiratory syncytial virus hospitalisation (RSVH) in preterm infants, a pooled analysis was undertaken of seven multicentre, prospective, observational studies from across the Northern Hemisphere (2000–2014). Data from all 320–356weeks' gestational age (wGA) infants without comorbidity were analysed. RSVH occurred in 534/14 504 (3.7%) infants; equating to a rate of 5.65per100 patient-seasons, with the rate in individual wGA groups dependent upon exposure time (P= 0.032). Most RSVHs (60.1%) occurred in December–January. Median age at RSVH was 88 days (interquartile range (IQR): 54–159). Respiratory support was required by 82.0% of infants: oxygen in 70.4% (median 4 (IQR: 2–6) days); non-invasive ventilation in 19.3% (median 3 (IQR: 2–5) days); and mechanical ventilation in 10.2% (median 5 (IQR: 3–7) days). Intensive care unit admission was required by 17.9% of infants (median 6 days (IQR: 2–8) days). Median overall hospital length of stay (LOS) was 5 (IQR: 3–8) days. Hospital resource use was similar across wGA groups except for overall LOS, which was shortest in those born 35 wGA (median 3vs.4–6 days for 32–34 wGA;P< 0.001). Strategies to reduce the burden of RSVH in otherwise healthy 32–35 wGA infants are indicated. |
| Databáze: | OpenAIRE |
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