The Metabolomic Rationale for Treating Perimenopausal Syndrome as Kidney Deficiency

Autor: Xueqin Chen, Junjie Lan, Candong Li, Wenna Liang, Huiying Huang, Cheng-Fu Li, Leqin Xu, Luwei Ruan, Tongjin Zhao, Shengyuan Lin, Tianwei Lin, Pengheng Zhang, Hongwei Yao, Zewei Zhuo, Haixia Ren, Bizhen Gao, Jianying Shen, Liu Hu, Caiming Wu
Rok vydání: 2020
Předmět:
Zdroj: Evidence-Based Complementary and Alternative Medicine, Vol 2020 (2020)
Evidence-based Complementary and Alternative Medicine : eCAM
ISSN: 1741-4288
1741-427X
DOI: 10.1155/2020/8568353
Popis: Background. Traditional Chinese medicine (TCM) typically attributes the etiopathogenesis of perimenopausal syndrome (PMS) to kidney deficiency in the TCM stratification system for diagnosis. However, the molecular basis of this classical attribution remains to be investigated. Aim of the Study. By unraveling the responses to TCM treatment for kidney deficiency, the metabolomic link between PMS and kidney deficiency can be evaluated for in-depth understanding of the mechanism of TCM treatment and development of better treatment protocols. Materials and Methods. With naturally aged rats as a model for PMS, the metabolomic response to TCM treatment for kidney deficiency was investigated by 1H NMR. Results. 1H NMR metabolomic evidence of plasma samples demonstrates that treatments with two classical TCM prescriptions for kidney deficiency, decoctions of Yougui and Zuogui, result in modulating the metabolic state of the disease model towards that of rats of younger age. Conclusion. The data support the notion that kidney deficiency is responsible, in part at least, for PMS, and the relevant prescriptions are helpful in dampening the changes in the body’s metabolic states to alleviate symptoms of the disorder.
Databáze: OpenAIRE
Externí odkaz: