Prospective validation and assessment of cardiovascular and offspring risk models for pregnant women with congenital heart disease
| Autor: | Balci, A., Sollie-Szarynska, K.M., Bijl, A.G.L. van der, Ruys, T.P.E., Mulder, B.J.M., Roos-Hesselink, J.W., Dijk, A.P.J. van, Wajon, E.M.C.J., Vliegen, H.W., Drenthen, W., Hillege, H.L., Aarnoudse, J.G., Veldhuisen, D.J. van, Pieper, P.G., ZAHARA 2 Investigators |
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| Přispěvatelé: | Cardiology, Life Course Epidemiology (LCE), Cardiovascular Centre (CVC), Groningen Kidney Center (GKC), ACS - Amsterdam Cardiovascular Sciences |
| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
Heart Defects
Congenital Pediatrics medicine.medical_specialty Heart disease Offspring Pregnancy Complications Cardiovascular Disease Risk Assessment RECOMMENDATIONS Decision Support Techniques ECHOCARDIOGRAPHIC-ASSESSMENT Predictive Value of Tests Pregnancy Risk Factors Germany Infant Mortality Humans Medicine Prospective Studies CARDIAC-DISEASE Prospective cohort study Fetal Death CARDIOLOGY OUTCOMES COMPLICATIONS Framingham Risk Score BLOOD-FLOW business.industry Other Research Radboud Institute for Health Sciences [Radboudumc 0] Infant Newborn Prognosis medicine.disease EUROPEAN-SOCIETY Maternal Mortality ROC Curve Area Under Curve Cohort Female Cardiology and Cardiovascular Medicine business Risk assessment SINGLE-CENTER TASK-FORCE |
| Zdroj: | Heart, 100(17), 1373-1381. BMJ Publishing Group Heart, 100(17), 1373-1381 Heart, 100(17), 1373-1381. BMJ PUBLISHING GROUP Heart (British Cardiac Society), 100(17), 1373-1381. BMJ Publishing Group Heart, 100, 1373-81 Heart, 100, 17, pp. 1373-81 |
| ISSN: | 1355-6037 |
| Popis: | Item does not contain fulltext OBJECTIVES: Adequate prepregnancy prediction of maternal cardiovascular and offspring risk is important for counselling and management of pregnancy in women with congenital heart disease (CHD). Therefore we performed a study to identify the optimal assessment strategy for estimating the risk of pregnancy in women with CHD. METHODS: In this prospective study, we determined the outcomes of 213 pregnancies in 203 women with CHD. The ZAHARA I (Zwangerschap bij Aangeboren HARtAfwijkingen I) and CARPREG (CARdiac disease in PREGnancy) risk scores were calculated for each pregnancy, as was the total number of cardiovascular (TPc) or offspring risk predictors (TPo) from these and other studies combined. Pregnancies were also classified according to the modified WHO classification of maternal cardiovascular risk and according to disease complexity (DC). RESULTS: Maternal cardiovascular events occurred during 22 pregnancies (10.3%). Offspring events occurred during 77 pregnancies in 81 children (37.3%). Cardiovascular and offspring event rates increased with higher risk scores, higher TPc or TPo, higher WHO class and greater DC. The highest area under the curve (AUC) for maternal cardiovascular risk was achieved by the WHO class (AUC: 0.77, p |
| Databáze: | OpenAIRE |
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