Radiation-Associated Endometrial Cancer
| Autor: | Sanjeev Kumar, Shelly Seward, Rouba Ali-Fehmi, Robert T. Morris, John M. Malone, Christopher S. Bryant, Jay P. Shah |
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| Rok vydání: | 2009 |
| Předmět: |
Oncology
Prognostic variable medicine.medical_specialty Neoplasms Radiation-Induced medicine.medical_treatment Kaplan-Meier Estimate Internal medicine medicine Humans Survival rate Cervix Aged Proportional Hazards Models Proportional hazards model business.industry Endometrial cancer Hazard ratio Obstetrics and Gynecology Cancer Neoplasms Second Primary Middle Aged medicine.disease United States Endometrial Neoplasms Radiation therapy medicine.anatomical_structure Female Radiotherapy Adjuvant business SEER Program |
| Zdroj: | Obstetrics & Gynecology. 113:319-325 |
| ISSN: | 0029-7844 |
| DOI: | 10.1097/aog.0b013e3181954c5b |
| Popis: | OBJECTIVE To compare prognostic variables and survival of radiation-associated endometrial cancers with sporadic second endometrial cancers. METHODS Patients with primary cancers of pelvic organs (urinary system, colorectal, cervix, vulva, and vagina) were identified from the Surveillance, Epidemiology, and End Results (SEER) database between 1973 and 2005. Among these patients, those who received pelvic radiation and subsequently developed endometrial cancer formed the radiation-associated endometrial cancers cohort (cases), whereas those who did not receive pelvic radiation but subsequently developed endometrial cancer formed the sporadic second endometrial cancers cohort (controls). Comparisons between radiation-associated endometrial cancers and sporadic second endometrial cancers used chi, t tests, Kaplan-Meier, and cox proportional hazards analysis. RESULTS In 205 radiation-associated endometrial cancer patients and 1,001 sporadic second endometrial cancer patients, the mean age of diagnosis was 65 years and 68 years, respectively (P |
| Databáze: | OpenAIRE |
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