Safety assessment of xylan by a 90-day feeding study in rats
| Autor: | Song Tang, Pingjing Wen, Huiyan Qin, Guangqiu Qin, Huili Liang, Yanwu Wang, Lujuan Zhang, Peng Zhao |
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| Rok vydání: | 2017 |
| Předmět: |
Male
0106 biological sciences 0301 basic medicine medicine.medical_specialty Urinalysis Administration Oral Physiology Toxicology 01 natural sciences Rats Sprague-Dawley 03 medical and health sciences Internal medicine Animals Medicine Cellulose No-Observed-Adverse-Effect Level Hematology medicine.diagnostic_test business.industry Blood biochemistry Toxicity Tests Subchronic General Medicine Xylan Rats Saccharum Biotechnology Subchronic toxicity 030104 developmental biology Systemic toxicity Toxicity Female Xylans business 010606 plant biology & botany Potential toxicity |
| Zdroj: | Regulatory Toxicology and Pharmacology. 85:1-6 |
| ISSN: | 0273-2300 |
| Popis: | Xylans are present naturally in various plants and have important uses in nutrition, food, novel material and biotechnology; however, to date, data regarding their systemic toxicity and safety evaluation is still limited. This study investigated the potential toxicity of xylan from sugarcane bagasse by a subchronic toxicity study in rats. A total of 80 male and female rats were fed with diets containing 10%, 5%, 2.5% and 0% (control) xylan for 90 days. A toxicological assessment was performed including mortality, body and organ weights, food consumption, blood biochemistry, hematology, urinalysis, gross necropsy and histopathological examinations. There were no signs of toxicity and treatment-related changes in rats treated with xylan. The no-observed-adverse-effect levels (NOAEL) of xylan were 9.0 g kg −1 bw for males and 10.6 g kg −1 bw for females of rats under this experimental condition, respectively. |
| Databáze: | OpenAIRE |
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