Overpressure blast-wave induced brain injury elevates oxidative stress in the hypothalamus and catecholamine biosynthesis in the rat adrenal medulla
| Autor: | Benedek Erdos, Philip J. Scarpace, Alexandra Sherman, Robert P. Yezierski, Nataliya Kirichenko, Firas Kobeissy, Stanislav I. Svetlov, Nihal Tümer, Kevin K.W. Wang, Victor Prima, Charles J. Vierck, Melissa A. Whidden |
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| Rok vydání: | 2013 |
| Předmět: |
Male
Sympathetic nervous system medicine.medical_specialty Hypothalamus medicine.disease_cause Rats Sprague-Dawley Catecholamines Blast Injuries Dopamine Internal medicine medicine Animals Tyrosine hydroxylase business.industry General Neuroscience Neuropeptide Y receptor Rats Up-Regulation Oxidative Stress medicine.anatomical_structure Endocrinology Adrenal Medulla Catecholamine Reactive Oxygen Species Adrenal medulla business Oxidative stress medicine.drug |
| Zdroj: | Neuroscience Letters. 544:62-67 |
| ISSN: | 0304-3940 |
| DOI: | 10.1016/j.neulet.2013.03.042 |
| Popis: | Explosive overpressure brain injury (OBI) impacts the lives of both military and civilian population. We hypothesize that a single exposure to OBI results in increased hypothalamic expression of oxidative stress and activation of the sympatho-adrenal medullary axis. Since a key component of blast-induced organ injury is the primary overpressure wave, we assessed selective biochemical markers of autonomic function and oxidative stress in male Sprague Dawley rats subjected to head-directed overpressure insult. Rats were subjected to single head-directed OBI with a 358kPa peak overpressure at the target. Control rats were exposed to just noise signal being placed at ~2m distance from the shock tube nozzle. Sympathetic nervous system activation of the adrenal medullae (AM) was evaluated at 6h following blast injury by assessing the expression of catecholamine biosynthesizing enzymes, tyrosine hydroxylase (TH), dopamine-β hydroxylase (DβH), neuropeptide Y (NPY) along with plasma norepinephrine (NE). TH, DβH and NPY expression increased 20%, 25%, and 91% respectively, following OBI (P |
| Databáze: | OpenAIRE |
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