Direct Noninvasive Assessment of Brain Metabolism during Increased Intracranial Pressure: Potential Therapeutic Vistas
| Autor: | G. W. Palladino, H. J. Proctor, Charles B. Cairns, D. Fillipo |
|---|---|
| Rok vydání: | 1986 |
| Předmět: |
Intracranial Pressure
Spectrophotometry Infrared Critical Care and Intensive Care Medicine Electron Transport Complex IV Hemoglobins Oxygen Consumption In vivo Animals Medicine Cerebral perfusion pressure Monitoring Physiologic Intracranial pressure CATS Inhalation business.industry Head injury Brain Oxygenation Carbon Dioxide medicine.disease Oxygen Cerebrovascular Circulation Oxyhemoglobins Anesthesia Cats Female Surgery business Perfusion |
| Zdroj: | The Journal of Trauma: Injury, Infection, and Critical Care. 26:863-868 |
| ISSN: | 0022-5282 |
| DOI: | 10.1097/00005373-198610000-00001 |
| Popis: | Intracranial pressure was increased in cats by infusing 'mock' CSF intracranially, thus decreasing cerebral perfusion and oxygenation. The cats then randomly received either 50% O2 or 50% O2-5% CO2 by inhalation. As monitored by in vivo near-infrared spectroscopy (NIR), no improvement was noted after 50% O2 whereas 50% O2-5% CO2 resulted in increased perfusion, an oxidation of cytochrome a,a3, an increase in oxyhemoglobin, and reduced quantities of de-oxyhemoglobin (p less than 0.01) despite a further increase in intracranial pressure. The authors conclude that: NIR is a useful means of noninvasively and directly assessing brain metabolism and has advantages over simple ICP monitoring; and continued investigations of CO2 as a possible therapeutic modality after head injury appear warranted. |
| Databáze: | OpenAIRE |
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