Negative prognostic implications of splenomegaly in nivolumab-treated advanced or recurrent pancreatic adenocarcinoma
| Autor: | Li-Chun Lu, Shih-Hung Yang, Ann-Lii Cheng, Yu-Wen Tien, Sung-Hsin Kuo, Bang-Bin Chen, Ting-Chun Kuo, Kun-Huei Yeh, Li Yuan Bai, Hsiang-Fong Kao |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
medicine.medical_treatment Immunology pancreatic cancer Adenocarcinoma Gastroenterology Targeted therapy Pancreatic cancer Internal medicine Antineoplastic Combined Chemotherapy Protocols Humans Immunology and Allergy Medicine RC254-282 nivolumab Chemotherapy business.industry Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC581-607 medicine.disease Gemcitabine Pancreatic Neoplasms Oncology Concomitant Splenomegaly spleen Folfirinox Regimen prognosis Neoplasm Recurrence Local Nivolumab Immunologic diseases. Allergy business Research Article medicine.drug |
| Zdroj: | OncoImmunology, Vol 10, Iss 1 (2021) Oncoimmunology article-version (VoR) Version of Record |
| Popis: | Immune checkpoint inhibitors have limited efficacy in the treatment of pancreatic ductal adenocarcinoma (PDAC). We investigated prognostic markers for nivolumab-based therapy in advanced or recurrent PDAC. Consecutive patients receiving nivolumab-based therapy at our institution between 2015 and 2020 were evaluated. Overall survival (OS) was analyzed through univariate and multivariate analyses. Spleen volume was estimated from the width, thickness, and length of the spleen. A total of 45 patients were identified. Biweekly nivolumab was administered as monotherapy (n = 5) or in combination with chemotherapy or targeted therapy (n = 40). Among 31 evaluable patients, the response and disease control rates were 7% and 36%, respectively. The baseline median spleen volume was 267 (110–674) mL. Patients with spleens ≥267 mL had significantly shorter median OS (1.9 months, 95% confidence interval [CI], 1.0–2.7) than did those with smaller spleens (8.2 months, 95% CI, 5.6–10.8; P = .003). In the multivariate analysis, spleen volume of |
| Databáze: | OpenAIRE |
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