Serotype-specific differences in short- and longer-term mortality following invasive pneumococcal disease
| Autor: | Lauren B. Wright, R. Gorton, K. E. Chapman, G. J. Hughes, Deborah Wilson |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Adult
0301 basic medicine Serotype medicine.medical_specialty Adolescent Epidemiology 030106 microbiology Serogroup Pneumococcal Infection medicine.disease_cause Pneumococcal Infections survival analysis Young Adult 03 medical and health sciences 0302 clinical medicine Internal medicine Streptococcus pneumoniae medicine Humans serotype 030212 general & internal medicine Mortality Child Survival analysis Aged Aged 80 and over business.industry Proportional hazards model Mortality rate Hazard ratio Infant Newborn Infant Middle Aged medicine.disease Original Papers Confidence interval Pneumococcal infections Infectious Diseases England Child Preschool Population Surveillance Immunology business |
| Zdroj: | Epidemiology and Infection |
| ISSN: | 1469-4409 0950-2688 |
| DOI: | 10.1017/s0950268816000856 |
| Popis: | SUMMARYInvasive pneumococcal disease (IPD), caused by infection with Streptococcus pneumoniae, has a substantial global burden. There are over 90 known serotypes of S. pneumoniae with a considerable body of evidence supporting serotype-specific mortality rates immediately following IPD. This is the first study to consider the association between serotype and longer-term mortality following IPD. Using enhanced surveillance data from the North East of England we assessed both the short-term (30-day) and longer-term (⩽7 years) independent adjusted associations between individual serotypes and mortality following IPD diagnosis using logistic regression and extended Cox proportional hazards models. Of the 1316 cases included in the analysis, 243 [18·5%, 95% confidence interval (CI) 16·4–20·7] died within 30 days of diagnosis. Four serotypes (3, 6A, 9N, 19 F) were significantly associated with overall increased 30-day mortality. Effects were observable only for older adults (⩾60 years). After extension of the window to 12 months and 36 months, one serotype was associated with significantly increased mortality at 12 months (19 F), but no individual serotypes were associated with increased mortality at 36 months. Two serotypes had statistically significant hazard ratios (HR) for longer-term mortality: serotype 1 for reduced mortality (HR 0·51, 95% CI 0·30–0·86) and serotype 9N for increased mortality (HR 2·30, 95% CI 1·29–4·37). The association with serotype 9N was no longer observed after limiting survival analysis to an observation period starting 30 days after diagnosis. This study supports the evidence for associations between serotype and short-term (30-day) mortality following IPD and provides the first evidence for the existence of statistically significant associations between individual serotypes and longer-term variation in mortality following IPD. |
| Databáze: | OpenAIRE |
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