Increased levels of inflammatory mediators and proinflammatory monocytes in patients with type I diabetes mellitus and nephropathy

Autor: Ingrid Benedicte Moss Kolseth, Trond Jenssen, Svein Olav Kolset, Amanda Sudworth, Trine M. Reine, Krystina Parker, Bartlomiej J Witczak
Rok vydání: 2016
Předmět:
0301 basic medicine
Male
endocrine system diseases
Endocrinology
Diabetes and Metabolism
Inflammation
030204 cardiovascular system & hematology
Systemic inflammation
Severity of Illness Index
Monocytes
Proinflammatory cytokine
Nephropathy
Diabetic nephropathy
03 medical and health sciences
0302 clinical medicine
Endocrinology
Diabetes mellitus
Plasminogen Activator Inhibitor 1
Internal Medicine
Human Umbilical Vein Endothelial Cells
Medicine
Humans
Diabetic Nephropathies
Renal Insufficiency
Endothelial dysfunction
Renal Insufficiency
Chronic
Cells
Cultured
Type 1 diabetes
business.industry
Middle Aged
medicine.disease
Intercellular Adhesion Molecule-1
Up-Regulation
030104 developmental biology
Diabetes Mellitus
Type 1
Immunology
Disease Progression
Leukocytes
Mononuclear
Kidney Failure
Chronic
Female
Endothelium
Vascular
medicine.symptom
Inflammation Mediators
business
Biomarkers
Diabetic Angiopathies
Zdroj: Journal of diabetes and its complications. 31(1)
ISSN: 1873-460X
Popis: Aims To investigate and describe the relationship between diabetic nephropathy and systemic inflammation in patients with type 1 diabetes mellitus (T1DM). Methods Patients with T1DM, with or without reduced renal function due to diabetic nephropathy, were included. Differences in inflammatory mediators, adhesion molecules, markers of endothelial dysfunction and subsets of monocytes were studied in patients with mean disease duration of 31 years. Results Patients with T1DM with and without renal failure were compared. Patients with nephropathy had increased plasma levels of proinflammatory monocytes, as well as circulatory PAI-1, syndecan-1, VEGF, IL-1β, IL-1Ra and CCL4. Peripheral blood mononuclear cells from patients with nephropathy numerically increased soluble ICAM and PAI-1 in co-culture with primary endothelial cells compared to cells from patients without nephropathy. Conclusions T1DM patients with kidney failure have higher levels of proinflammatory monocytes and circulatory inflammatory mediators compared to patients with T1DM alone. The results highlight the importance of inflammation and endothelial dysfunction in diabetic nephropathy with reduced GFR.
Databáze: OpenAIRE
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