Management versus miscues in the cytosolic labile iron pool: The varied functions of iron chaperones
| Autor: | Olga Protchenko, Sarju J. Patel, Caroline C. Philpott |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Iron-Sulfur Proteins Iron Raw material Cofactor Article 03 medical and health sciences Cytosol Ferroptosis Humans Molecular Biology 030102 biochemistry & molecular biology biology Chemistry RNA-Binding Proteins Cell Biology Glutathione DNA-Binding Proteins Fatty Liver 030104 developmental biology Biochemistry biology.protein Function (biology) Intracellular Molecular Chaperones |
| Zdroj: | Biochim Biophys Acta Mol Cell Res |
| ISSN: | 1879-2596 |
| Popis: | Iron-containing proteins rely on the incorporation of a set of iron cofactors for activity. The cofactors must be synthesized or assembled from raw materials located within the cell. The chemical nature of this pool of raw material - referred to as the labile iron pool - has become clearer with the identification of micro- and macro-molecules that coordinate iron within the cell. These molecules function as a buffer system for the management of intracellular iron and are the focus of this review, with emphasis on the major iron chaperone protein coordinating the labile iron pool: poly C-binding protein 1. |
| Databáze: | OpenAIRE |
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