Plasma levels of thrombomodulin, plasminogen activator inhibitor-1 and fibrinogen in elderly, diabetic patients with depressive symptoms
| Autor: | Jerzy Loba, Anna Borkowska, Małgorzata Górska-Ciebiada, Maciej Ciebiada, Małgorzata Saryusz-Wolska |
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| Jazyk: | angličtina |
| Předmět: |
Male
Aging medicine.medical_specialty Thrombomodulin Statistics as Topic PAI-1 Neuropsychological Tests Fibrinogen 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Risk Factors Internal medicine Diabetes mellitus Plasminogen Activator Inhibitor 1 medicine Humans Prospective Studies Prospective cohort study Depressive symptoms Depression (differential diagnoses) Aged Depression business.industry Diabetes Cholesterol LDL Plasma levels medicine.disease 030227 psychiatry Ageing Endocrinology Diabetes Mellitus Type 2 chemistry Plasminogen activator inhibitor-1 cardiovascular system Female Original Article Geriatrics and Gerontology business Biomarkers 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Aging Clinical and Experimental Research |
| ISSN: | 1720-8319 |
| DOI: | 10.1007/s40520-015-0504-3 |
| Popis: | Background Diabetes, depression and aging have been associated with pro-inflammatory and prothrombotic state. Aim The aim of the study was to determine the plasma levels of thrombomodulin, plasminogen activator inhibitor-1 (PAI-1) and fibrinogen in elderly diabetic patients with and without depressive symptoms and to examine factors (including thrombomodulin, PAI-1, fibrinogen levels) associated with depressive symptoms in elderly patients with type 2 diabetes (T2DM). Methods A total of 276 T2DM elders were evaluated: 82 subjects with depressive symptoms and 194 controls. Data were collected concerning biochemical parameters and biomarkers. Results Plasma thrombomodulin, PAI-1 and fibrinogen were elevated in patients with depressive symptoms compared to controls. Thrombomodulin level was correlated with fibrinogen and PAI-1 levels. All parameters were correlated with the Geriatric Depression Scale-30 score. The univariate logistic regression models revealed that variables which increased the likelihood of diagnosis of depressive symptoms in elderly patients with T2DM were: female sex, smoking habit, longer duration of T2DM, hyperlipidemia, neuropathy, increased number of co-morbidities, higher BMI, and higher levels of total and LDL cholesterol, thrombomodulin, PAI-1 and fibrinogen. In addition, the multivariable analysis indicated that female sex, smoking habit, increased number of co-morbidities, higher BMI, and higher levels of LDL cholesterol and thrombomodulin are the predisposing factors for depressive symptoms. Conclusions Elderly diabetic patients with depressive symptoms have higher levels of thrombomodulin, PAI-1 and fibrinogen. Further prospective larger studies are needed to provide potential directions for the research, treatment and prevention of co-morbid depression and diabetes. |
| Databáze: | OpenAIRE |
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