Mucosal inflammation in Candida esophagitis has distinctive features that may be helpful diagnostically
| Autor: | Joel A. Lefferts, Isabella W. Martin, Xiaoying Liu, Arief A. Suriawinata, Aaron E Atkinson, Mikhail Lisovsky |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Adult Male Pathology medicine.medical_specialty Neutrophils Mucosal inflammation Basal Cell Hyperplasia Pathology and Forensic Medicine 03 medical and health sciences 0302 clinical medicine Medicine Esophagitis Humans Reflux esophagitis Aged Retrospective Studies Inflammation Mucous Membrane business.industry Candida esophagitis Candidiasis Middle Aged medicine.disease Epithelium 030104 developmental biology medicine.anatomical_structure 030220 oncology & carcinogenesis Etiology Intraepithelial lymphocyte Female business |
| Zdroj: | Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc. 31(11) |
| ISSN: | 1530-0285 |
| Popis: | The diagnosis of Candida esophagitis can be challenging when the epithelium containing Candida filamentous forms is not readily seen or is entirely sloughed away. Mucosal inflammation could be helpful diagnostically, if distinctive. However it is thought to be nonspecific in Candida esophagitis. The goal of this retrospective study was to identify features of mucosal inflammation helpful in alerting a pathologist to the possibility of Candida esophagitis when Candida mycelia are not readily observed. The study group consisted of 99 consecutive cases of Candida esophagitis and a control group of 64 consecutive cases of reflux esophagitis diagnosed at our institution from 2008–2016. Band-like superficial intraepithelial neutrophils and increased intraepithelial lymphocytes were observed in 75 and 67% of Candida esophagitis cases, respectively and only in 14 and 19% of reflux esophagitis cases, respectively (p |
| Databáze: | OpenAIRE |
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