Effect of intraoperative amino acid infusion on blood glucose under general anesthesia combined with epidural block
| Autor: | Xiao Feng Zhuang, Jing Cang, Zhang Gang Xue, Jing Zhong, Sheng Jin Ge |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
Adult
Anesthesia Epidural Blood Glucose Male Ringer's Lactate Adolescent medicine.medical_treatment Medicine (miscellaneous) Hypothermia Anesthesia General Glucagon Young Adult Insulin Secretion Medicine Humans Insulin In patient Amino Acids Infusions Intravenous chemistry.chemical_classification Nutrition and Dietetics Skin incision C-Peptide business.industry Middle Aged Amino acid chemistry Anesthesia Epidural block Female medicine.symptom Isotonic Solutions business Amino acid infusion |
| Zdroj: | Annals of nutritionmetabolism. 61(1) |
| ISSN: | 1421-9697 |
| Popis: | Aim: To investigate the effect of intraoperative amino acid infusion on blood glucose in patients under general anesthesia combined with epidural block. Methods: 36 patients were randomly assigned to receive an intraoperative infusion of 18 compound amino acids (group AA) or lactated Ringer solution (group LR) at 2 ml·kg–1·h–1. Nasopharyngeal temperature, and blood glucose, plasma insulin, C-peptide and glucagon concentrations were measured 30 min before induction (T0), 10 min after induction (T1), 30 min and 2 h after skin incision (T2, T3), and 30 min and 2 h postoperatively (T4, T5). Results: Nasopharyngeal temperature values, which decreased during surgery in both groups, were significantly higher in group AA than in group LR from T3 to T5. Compared with T0, the blood glucose concentration increased significantly from T2 in group AA and T3 in group LR to T5. Plasma insulin and C-peptide concentrations did not change significantly in group LR, while both increased significantly in group AA from T1 to T4. The plasma glucagon concentration did not change significantly in either group. Conclusion: Intraoperative amino acid infusion in patients under general anesthesia combined with epidural block may accelerate the increase of blood glucose concentration and stimulate insulin secretion, and can alleviate hypothermia during the later period of surgery and postoperatively. |
| Databáze: | OpenAIRE |
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