Differential gender effects of a reduced-calorie diet on systemic inflammatory and immune parameters in nonhuman primates
| Autor: | Karen F. Novak, Dolphus R. Dawson, J. L. Ebersole, G. L. Branch-Mays, J. C. Gunsolley, M. J. Steffen, Julie A. Mattison, Donald K. Ingram, Mark A. Reynolds, M. J. Novak |
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| Rok vydání: | 2008 |
| Předmět: |
Male
Aging medicine.medical_specialty Calorie restriction Article Immunoglobulin G Bacteria Anaerobic Sex Factors Immune system stomatognathic system Internal medicine medicine Animals Immunity Mucosal Periodontal Diseases Caloric Restriction Inflammation biology Prevotella intermedia Acute-phase protein Campylobacter rectus Treponema denticola biology.organism_classification Antibodies Bacterial Macaca mulatta stomatognathic diseases Endocrinology Linear Models biology.protein Periodontics Female Fusobacterium nucleatum Acute-Phase Proteins |
| Zdroj: | Journal of Periodontal Research. 43:500-507 |
| ISSN: | 1600-0765 0022-3484 |
| Popis: | Background and Objective: Dietary manipulation, including caloric restriction, has been shown to impact host response capabilities significantly, particularly in association with aging. This investigation compared systemic inflammatory and immune-response molecules in rhesus monkeys (Macaca mulatta). Material and Methods: Monkeys on continuous long-term calorie-restricted diets and a matched group of animals on a control ad libitum diet, were examined for systemic response profiles including the effects of both gender and aging. Results: The results demonstrated that haptoglobin and α1-antiglycoprotein levels were elevated in the serum of male monkeys. Serum IgG responses to Campylobacter rectus, Actinobacillus actinomycetemcomitans and Porphyromonas gingivalis were significantly elevated in female monkeys. While only the antibody to Fusobacterium nucleatum was significantly affected by the calorie-restricted diet in female monkeys, antibody levels to Prevotella intermedia, C. rectus and Treponema denticola demonstrated a similar trend. Conclusion: In this investigation, only certain serum antibody levels were influenced by the age of male animals, which was seemingly related to increasing clinical disease in this gender. More generally, analytes were modulated by gender and/or diet in this oral model system of mucosal microbial challenge. |
| Databáze: | OpenAIRE |
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