Effects of age and streptozotocin-induced diabetes on biogenic amines in rat tail artery
| Autor: | Subramanian Dhanasekaran, J.F.B. Morrison, Rajan Sheen |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
Blood Glucose
Male Tail Biogenic Amines medicine.medical_specialty Sympathetic nervous system Clinical chemistry Clinical Biochemistry Diabetes Mellitus Experimental Internal medicine Diabetes mellitus Mole medicine Animals Rats Wistar Molecular Biology Diabetic Autonomic Neuropathy Chemistry Age Factors Arteries Cell Biology General Medicine medicine.disease Streptozotocin Rats Autonomic nervous system medicine.anatomical_structure Endocrinology Axoplasmic transport medicine.drug |
| Zdroj: | Molecular and Cellular Biochemistry. 261:77-82 |
| ISSN: | 0300-8177 |
| DOI: | 10.1023/b:mcbi.0000028740.25738.4a |
| Popis: | The changes in amine concentrations in different segments of the rat tail artery have been investigated at different ages and after different durations of streptozotocin-induced diabetes. There was a significant positive slope to the relationship between amine concentrations and age in proximal portion of the normal tail artery, and a significant additional increase in amine concentrations following induction of diabetes. The peak of the latter response occurred between 10 and 20 weeks following the induction of diabetes. There was also a significant dependence on the length of the post-ganglionic neurones, which may be related to the failure of axonal transport of some of the essential enzymes or transporters for these biogenic amines. This model of altered catecholamine metabolism and handling requires further investigation so that alterations in the mechanisms involved in processing of these amines in diabetic autonomic neuropathy may be elucidated. (Mol Cell Biochem 261: 77–82, 2004) |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink