Pathophysiological mechanisms of vascular calcification
| Autor: | Lucie, Hénaut, Romuald, Mentaverri, Sophie, Liabeuf, Anne-Sophie, Bargnoux, Pierre, Delanaye, Étienne, Cavalier, Jean-Paul, Cristol, Ziad, Massy, Said, Kamel, L, Pieroni |
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| Přispěvatelé: | Mécanismes physiopathologiques et conséquences des calcifications vasculaires - UR UPJV 7517 (MP3CV), Université de Picardie Jules Verne (UPJV)-CHU Amiens-Picardie, Mécanismes physiologiques et conséquences des calcifications cardiovasculaires: rôle des remodelages cardiovasculaires et osseux, Université de Picardie Jules Verne (UPJV)-Institut National de la Santé et de la Recherche Médicale (INSERM), CHU Amiens-Picardie, Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] (PhyMedExp), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Centre Hospitalier Universitaire de Liège (CHU-Liège), Université de Picardie Jules Verne (UPJV) |
| Rok vydání: | 2015 |
| Předmět: |
[SDV]Life Sciences [q-bio]
Population 030232 urology & nephrology Osteoclasts Disease Bioinformatics 030226 pharmacology & pharmacy 03 medical and health sciences 0302 clinical medicine Diabetes mellitus Humans Medicine education Vascular calcification ComputingMilieux_MISCELLANEOUS education.field_of_study diabetes business.industry Cellular process media General Medicine medicine.disease Pathophysiology Increased risk vascular calcification osteoblast vascular smooth muscle cell business chronic kidney disease intima Kidney disease |
| Zdroj: | Annales de Biologie Clinique Annales de Biologie Clinique, John Libbey Eurotext, 2015, pp.271-87. ⟨10.1684/abc.2015.1044⟩ |
| ISSN: | 0003-3898 |
| Popis: | Vascular calcification (VC) is a degenerative pathology of the vessel wall. In the general population, VC appearance is associated with aging, but this pathology can also develop as a consequence of atherosclerosis, diabetes, inflammatory and chronic kidney disease. VC is strongly associated with increased risk of mortality and cardiovascular disease. Although VC has long been considered as the result of a passive precipitation of mineral, it is now well established that this pathology results from an active and highly regulated cellular process, which shares similarities with bone formation. This review summarizes our current knowledge on VC formation, and details the modalities of action of the main actors known to modulate this process. |
| Databáze: | OpenAIRE |
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