Topical 5-Fluorouracil in Treating Epithelial Neoplasia of the Conjunctiva and Cornea
| Autor: | Jerry G. Ford, Constance A. Stanton, John W. Reed, R. Patrick Yeatts |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
Adult
Male Antimetabolites Antineoplastic medicine.medical_specialty Conjunctiva Administration Topical Biopsy Eye disease medicine.medical_treatment Conjunctival Neoplasms Corneal Diseases Cornea Carcinoma Humans Medicine Aged Chemotherapy business.industry Eye Neoplasms Middle Aged medicine.disease Dermatology Surgery Ophthalmology Artificial tears Treatment Outcome medicine.anatomical_structure Chemotherapy Adjuvant Fluorouracil Adjunctive treatment Female Ophthalmic Solutions business Carcinoma in Situ Follow-Up Studies medicine.drug |
| Zdroj: | Ophthalmology. 102:1338-1344 |
| ISSN: | 0161-6420 |
| DOI: | 10.1016/s0161-6420(95)30866-4 |
| Popis: | Purposes: To evaluate the efficacy of topical 5-fluorouracil (5-FU) in treating conjunctival and corneal epithelial neoplasia. Methods: Three patients underwent surgical excision of bulky disease followed by topical 1 % 5-FU in artificial tear base for 2 to 3 weeks or until epithelial separation occurred. An additional three patients underwent treatment with topical 1 % 5-FU alone. Results: Minimum follow-up was 6 months. In one patient with conjunctival in situ carcinoma and no detectable normal conjunctiva, who had normal findings on conjunctival histologic examination after application of topical 5-FU, a focus of invasive disease requiring orbital exenteration. One patient had a favorable response to 5-FU therapy but required a repeat excision for control of bulky disease. Four patients have remained disease-free for 10, 13, 18, and 30 months after topical 5-FU therapy. Conclusion: With its potential selective toxicity on dysplastic epithelium, topical 5FU shows promise as an adjunctive treatment for managing conjunctival and corneal epithelial neoplasia. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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