Reduced pulmonary microvascular permeability in severe chronic left heart failure
| Autor: | J Bailey, R Balcon, Simon W. Davies, DP Lipkin, Robin M. Rudd, Jennifer Keegan |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
Male
medicine.medical_specialty Pathology Erythrocytes Heart disease Vascular permeability Scintigraphy Ventricular Function Left Capillary Permeability Coronary artery disease Internal medicine medicine Humans Pulmonary Wedge Pressure Radionuclide Imaging Lung Aged Heart Failure medicine.diagnostic_test business.industry Indium Radioisotopes Transferrin Technetium Pulmonary edema medicine.disease medicine.anatomical_structure Heart failure Cardiology Female Cardiology and Cardiovascular Medicine business Complication |
| Zdroj: | American Heart Journal. 124:137-142 |
| ISSN: | 0002-8703 |
| DOI: | 10.1016/0002-8703(92)90931-k |
| Popis: | Pulmonary edema is a serious complication of heart failure, but often patients with chronic heart failure resist pulmonary edema despite elevated pulmonary venous pressures. This protection might be a result of decreased pulmonary microvascular permeability. Double-isotope scintigraphy with 113mindium-labeled transferrin and 99mtechnetium-labeled erythrocytes allows noninvasive estimation of pulmonary microvascular permeability; an index of transferrin accumulation is calculated that reflects microvascular permeability. Fourteen patients with severe chronic left ventricular dysfunction were compared with a control group of 15 patients with mild coronary artery disease. In the control group the transferrin accumulation index was 0.35 (range -0.3 to 1.0) x 10(-3)/min, and in patients with heart failure the index was 0.0 (range -1.0 to 0.7) x 10(-3)/min, which was significantly lower (p less than 0.01). The reduction in the transferrin accumulation index correlated weakly with the duration of heart failure (R = -0.5, p less than 0.02). These data indicate reduced protein efflux consistent with a decrease in pulmonary microvascular permeability in patients with severe chronic heart failure. Similar changes have been observed in severe mitral stenosis and may reflect a generalized adaptation to chronic pulmonary venous hypertension. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|