Synthesis and vesicle formation of a nido-carborane cluster lipid for boron neutron capture therapy
| Autor: | Nakamura, Hiroyuki, Miyajima, Y, Takei, T, Kasaoka, S, Maruyama, K |
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| Rok vydání: | 2004 |
| Předmět: |
Liposome
Chromatography Vesicle Metals and Alloys Uranyl acetate General Chemistry Negative stain Catalysis Surfaces Coatings and Films Electronic Optical and Magnetic Materials Calcein chemistry.chemical_compound chemistry Transmission electron microscopy Materials Chemistry Ceramics and Composites Carborane Moiety lipids (amino acids peptides and proteins) Nuclear chemistry |
| Zdroj: | Chemical communications (Cambridge, England). (17) |
| ISSN: | 1359-7345 |
| Popis: | The nido-carborane lipid 2, which has a double-tailed moiety, was synthesized from heptadecanol in 5 steps. Analysis in a transmission electron microscope by negative staining with uranyl acetate showed that the lipid 2 formed a stable vesicle in which calcein was encapsulated. The lipid 2 was incorporated into distearoylphosphatidylcholine (DSPC) liposomes at a very high concentration. |
| Databáze: | OpenAIRE |
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