An early diagnostic tool for diabetic peripheral neuropathy in rats
| Autor: | Marit H. N. van Velzen, Shoista Kambiz, Naim Avazverdi, Steven E.R. Hovius, Joop A. M. J. L. Janssen, Johan W. van Neck, Saniye G. Cosgun, Erik T Walbeehm |
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| Přispěvatelé: | Plastic and Reconstructive Surgery and Hand Surgery, Erasmus MC other, Anesthesiology, Internal Medicine, Developmental Biology |
| Rok vydání: | 2015 |
| Předmět: |
medicine.medical_specialty
Diabetic neuropathy Blood sugar lcsh:Medicine SDG 3 - Good Health and Well-being Internal medicine Diabetes mellitus medicine lcsh:Science Multidisciplinary integumentary system business.industry lcsh:R Blood flow medicine.disease Streptozotocin Reconstructive and regenerative medicine Radboud Institute for Health Sciences [Radboudumc 10] medicine.anatomical_structure Peripheral neuropathy Endocrinology Anesthesia lcsh:Q Decreased motor nerve conduction velocity Pancreas business medicine.drug Research Article |
| Zdroj: | PLoS ONE, Vol 10, Iss 5, p e0126892 (2015) PLoS One, 10, 5 PLoS ONE PLoS One (print), 10(5). Public Library of Science PLoS One, 10 |
| ISSN: | 1932-6203 |
| Popis: | Contains fulltext : 153977.PDF (Publisher’s version ) (Open Access) The skin's rewarming rate of diabetic patients is used as a diagnostic tool for early diagnosis of diabetic neuropathy. At present, the relationship between microvascular changes in the skin and diabetic neuropathy is unclear in streptozotocin (STZ) diabetic rats. The aim of this study was to investigate whether the skin rewarming rate in diabetic rats is related to microvascular changes and whether this is accompanied by changes observed in classical diagnostic methods for diabetic peripheral neuropathy. Computer-assisted infrared thermography was used to assess the rewarming rate after cold exposure on the plantar skin of STZ diabetic rats' hind paws. Peripheral neuropathy was determined by the density of intra-epidermal nerve fibers (IENFs), mechanical sensitivity, and electrophysiological recordings. Data were obtained in diabetic rats at four, six, and eight weeks after the induction of diabetes and in controls. Four weeks after the induction of diabetes, a delayed rewarming rate, decreased skin blood flow and decreased density of IENFs were observed. However, the mechanical hyposensitivity and decreased motor nerve conduction velocity (MNCV) developed 6 and 8 weeks after the induction of diabetes. Our study shows that the skin rewarming rate is related to microvascular changes in diabetic rats. Moreover, the skin rewarming rate is a non-invasive method that provides more information for an earlier diagnosis of peripheral neuropathy than the classical monofilament test and MNCV in STZ induced diabetic rats. |
| Databáze: | OpenAIRE |
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