Synthesis and antitumor properties of 7-deoxy-7-[(cis- and trans-3-aminocyclohexane)thio]carminomycinone
| Autor: | Terrence W. Doyle, John M. Essery, Richard H. Schreiber |
|---|---|
| Rok vydání: | 1979 |
| Předmět: |
Stereochemistry
Carubicin Daunorubicin Carminomycinone Molecular Conformation Thio Antineoplastic Agents Stereoisomerism Microbial Sensitivity Tests Bacteriophage lambda chemistry.chemical_compound Daunosamine chemistry Drug Discovery Molecular Medicine Virus Activation Cis–trans isomerism Bacillus subtilis |
| Zdroj: | Journal of Medicinal Chemistry. 22:1425-1428 |
| ISSN: | 1520-4804 0022-2623 |
| Popis: | The synthesis of analogues of carminomycin in which the daunosamine group has been replaced by (cis- and trans-3-aminocyclohexane)thio moieties is described. The new compounds were found to exhibit none of the antitumor or antibiotic activity associated with carminomycin. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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