Fluorene-9-bisphenol is anti-oestrogenic and may cause adverse pregnancy outcomes in mice
| Autor: | Xiaolin Fan, Tsuyoshi Nakanishi, Xuan Xiao, Junyu Li, Xuan Guo, Zhaobin Zhang, Desheng Zhu, Tong Yu, Yi Wan, Jianying Hu, Youhei Hiromori, Jun Li, Siyu Cheng, Jilong Guo, Libei Sun, Ying Hu |
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| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Bisphenol A Bisphenol Proton Magnetic Resonance Spectroscopy General Physics and Astronomy 010501 environmental sciences Bioinformatics 01 natural sciences chemistry.chemical_compound Human health Mice Pregnancy Catalytic Domain Toxicity Tests Chronic Multidisciplinary Estradiol Reproduction Estrogen Antagonists Pregnancy Outcome Environmental exposure Healthy Volunteers Molecular Docking Simulation MCF-7 Cells Female Plastics hormones hormone substitutes and hormone antagonists medicine.medical_specialty endocrine system Science General Biochemistry Genetics and Molecular Biology Article 03 medical and health sciences Phenols Internal medicine medicine Animals Humans Benzhydryl compounds Benzhydryl Compounds Carbon-13 Magnetic Resonance Spectroscopy Pregnancy outcomes Adverse effect Students 0105 earth and related environmental sciences Fluorenes business.industry urogenital system Gene Expression Profiling Estrogen Receptor alpha General Chemistry Environmental Exposure medicine.disease 030104 developmental biology Endocrinology chemistry Gene Expression Regulation business |
| Zdroj: | Nature Communications Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017) |
| ISSN: | 2041-1723 |
| Popis: | Bisphenol A (BPA) is used in the production of plastic but has oestrogenic activity. Therefore, BPA substitutes, such as fluorene-9-bisphenol (BHPF), have been introduced for the production of so-called ‘BPA-free' plastics. Here we show that BHPF is released from commercial ‘BPA-free' plastic bottles into drinking water and has anti-oestrogenic effects in mice. We demonstrate that BHPF has anti-oestrogenic activity in vitro and, in an uterotrophic assay in mice, induces low uterine weight, atrophic endometria and causes adverse pregnancy outcomes, even at doses lower than those of BPA for which no observed adverse effect have been reported. Female mice given water containing BHPF released from plastic bottles, have detectable levels of BHPF in serum, low uterine weights and show decreased expressions of oestrogen-responsive genes. We also detect BHPF in the plasma of 7/100 individuals, who regularly drink water from plastic bottles. Our data suggest that BPA substitutes should be tested for anti-oestrogenic activity and call for further study of the toxicological effects of BHPF on human health. Bisphenol A is used in the production of many plastic products, but has adverse health effects and is therefore being replaced. Here the authors show that its substitute, fluorene-9-bisphenol, is released from commercial plastic bottles into drinking water, and has anti-oestrogenic effects in mice. |
| Databáze: | OpenAIRE |
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