Effect of manipulative reduction combined with air enema on intestinal mucosal immune function in children with intussusception
| Autor: | Yu-Kun Bai, Han-Liang Jiao, Ping Wang, Yang Li |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Air enema Manipulative reduction medicine.medical_treatment Peritonitis Gastroenterology law.invention 03 medical and health sciences 0302 clinical medicine Immune system Randomized controlled trial law 030225 pediatrics Intussusception (medical disorder) Internal medicine medicine 030212 general & internal medicine Intestinal mucosal immune function Reduction (orthopedic surgery) business.industry General Medicine Enema medicine.disease Pediatric intussusception Original Article business Reperfusion injury |
| Zdroj: | Pakistan Journal of Medical Sciences |
| ISSN: | 1681-715X 1682-024X |
| DOI: | 10.12669/pjms.36.7.3105 |
| Popis: | Objective: To explore the effect of manipulative reduction combined with air enema on intestinal mucosal immune function in children with intussusception. Methods: This is a prospective randomized controlled study in which 60 children with primary intussusception admitted to Hebei Children’s Hospital from October 2018 to October 2019 were selected for this study. They were randomly divided into two groups. The 30 patients in the experimental group underwent manipulative reduction and air enema reduction, and 30 patients in the control group underwent only air enema reduction. Pain scores and pressure during enema were recorded and analyzed. Fasting blood of children in the experimental group were drawn to test the serum T lymphocyte subsets CD3+, CD4+, CD8+ levels, B lymphocyte subsets CD19+ level, and NK cell subsets CD56+ levels before reduction. Among them, fasting blood of 28 children with successful reduction were drawn again in the morning after reduction, and the indicators of each immune cell subgroup before and after reduction were analyzed. Two children with unsuccessful reduction were no longer tested for these indicators. Results: Twenty-Eight children in the experimental group had successful reduction, and two children with unsuccessful reduction were changed to open surgery (28/30). Twenty five Children in the control group had successful reduction, and five were changed to open surgery (25/30). There was no significant difference in the success rate of reduction between two groups (p>0.05). Close observation for 12~24h after reduction found that none of the children had signs of peritonitis. The pain score and reduction pressure of the observation group were lower than those of the control group, and the difference was statistically significant (p |
| Databáze: | OpenAIRE |
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