In vivo and in vitro evaluation of the heparin management test versus the activated coagulation time for monitoring anticoagulation level in aprotinin-treated patients during cardiac surgery
| Autor: | J. M. Murkin, S. J. Adams, Y. S. Kim |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
Adult
Male medicine.medical_specialty Pharmacology Sensitivity and Specificity Hemostatics chemistry.chemical_compound Aprotinin In vivo Internal medicine Statistical significance medicine Humans Cardiac Surgical Procedures Blood Coagulation Whole blood Aged Intraoperative Care business.industry Heparin Factor X Anticoagulants Reproducibility of Results Thrombosis Middle Aged Cardiac surgery Treatment Outcome chemistry Cardiology Surgery Female Blood Coagulation Tests Cardiology and Cardiovascular Medicine Activated Coagulation Time business hormones hormone substitutes and hormone antagonists medicine.drug |
| Zdroj: | The heart surgery forum. 7(6) |
| ISSN: | 1522-6662 |
| Popis: | INTRODUCTION Monitoring whole blood anticoagulation therapy with the activated coagulation time (kaolin ACT) and the heparin management test (HMT) were correlated in vivo with the plasma anti-activated factor X (anti-Xa) heparin concentration in patients who received variable doses of aprotinin and in vitro in the presence of increasing concentrations of aprotinin. METHODS In 38 elective cardiac surgical patients who received an average heparin dose of 400 IU/kg and an average total aprotinin dose of 3.6 10(6) kallikrein-inhibiting units (KIU), ACT and HMT were measured in duplicate 6 times intraoperatively at predetermined intervals. Blood samples at each interval were also assayed for the anti-Xa plasma heparin concentration with the IL Test heparin chromogenic assay. The influence of increasing concentrations of aprotinin on HMT and ACT was also measured in vitro by using blood samples containing 6 IU/mL heparin from 6 additional patients after adding specific aliquots of aprotinin to achieve concentrations of 50, 100, 200, and 300 KIU/mL aprotinin. Linear regression analysis was used to compare HMT and ACT against anti-Xa. A P level |
| Databáze: | OpenAIRE |
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