Insights on Foxn1 Biological Significance and Usages of the 'Nude' Mouse in Studies of T-Lymphopoiesis
| Autor: | Zhijie Zhang, Brandon Coder, Preston Burnley, Dong-Ming Su |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Genetically modified mouse
Mice Nude Review Thymus Gland Biology Applied Microbiology and Biotechnology Mice 03 medical and health sciences 0302 clinical medicine Nude mouse Animals Lymphopoiesis T-Lymphopoiesis Molecular Biology Ecology Evolution Behavior and Systematics Gene knockout 030304 developmental biology 0303 health sciences integumentary system Research FOXN1 Gene targeting Forkhead Transcription Factors Cell Biology FoxN1 gene biology.organism_classification 3. Good health Hairless Cell biology 030220 oncology & carcinogenesis Gene Targeting Models Animal Immunology Knockout mouse Developmental Biology |
| Zdroj: | International Journal of Biological Sciences |
| ISSN: | 1449-2288 |
| DOI: | 10.7150/ijbs.5033 |
| Popis: | Mutation in the "nude" gene, i.e. the FoxN1 gene, induces a hairless phenotype and a rudimentary thymus gland in mice (nude mouse) and humans (T-cell related primary immunodeficiency). Conventional FoxN1 gene knockout and transgenic mouse models have been generated for studies of FoxN1 gene function related to skin and immune diseases, and for cancer models. It appeared that FoxN1's role was fully understood and the nude mouse model was fully utilized. However, in recent years, with the development of inducible gene knockout/knockin mouse models with the loxP-Cre(ER(T)) and diphtheria toxin receptor-induced cell abolished systems, it appears that the complete repertoire of FoxN1's roles and deep-going usage of nude mouse model in immune function studies have just begun. Here we summarize the research progress made by several recent works studying the role of FoxN1 in the thymus and utilizing nude and "second (conditional) nude" mouse models for studies of T-cell development and function. We also raise questions and propose further consideration of FoxN1 functions and utilizing this mouse model for immune function studies. |
| Databáze: | OpenAIRE |
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