Rectal Dose–Volume Differences Using Proton Radiotherapy and a Rectal Balloon or Water Alone for the Treatment of Prostate Cancer
| Autor: | Carlos Vargas, Chaitali Mahajan, Kenneth Oliver, Sameer R. Keole, Amber Fryer, Paula Lawlor, Randal H. Henderson, Zuofeng Li, David Horne, Craig R. M. McKenzie, Angela Chellini, Daniel J. Indelicato |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
Male
Cancer Research medicine.medical_treatment Rectum Catheterization Prostate cancer Proton radiation Prostate Proton Therapy medicine Humans Radiology Nuclear Medicine and imaging Radiation Injuries Proton therapy Radiation business.industry Radiotherapy Planning Computer-Assisted Prostatic Neoplasms Seminal Vesicles Water Radiotherapy Dosage medicine.disease Magnetic Resonance Imaging Radiation therapy medicine.anatomical_structure Oncology Rectal Balloon Tomography X-Ray Computed Nuclear medicine business Endorectal coil |
| Zdroj: | International Journal of Radiation Oncology*Biology*Physics. 69:1110-1116 |
| ISSN: | 0360-3016 |
| DOI: | 10.1016/j.ijrobp.2007.04.075 |
| Popis: | To describe dose-volume values with the use of water alone vs. a rectal balloon (RB) for the treatment of prostate cancer with proton therapy.We analyzed 30 proton plans for 15 patients who underwent CT and MRI scans with an RB or water alone. Simulation was performed with a modified MRI endorectal coil and an RB with 100 mL of water or water alone. Doses of 78-82 gray equivalents were prescribed to the planning target volume. The two groups were compared for three structures: rectum, rectal wall (RW), and rectal wall 7 cm (RW7) at the level of the planning target volume.Rectum and RW volumes radiated to low, intermediate, and high doses were small: rectum V10, 33.7%; V50, 17.3%; and V70, 10.2%; RW V10, 32.4%; V50, 20.4%; and V70, 14.6%. The RB effectively increased the rectal volume for all cases (139.8 +/- 44.9 mL vs. 217.7 +/- 32.2 mL (p0.001). The RB also decreased the volume of the rectum radiated to doses V10-V65 (por = 0.05); RW for V10-V50; and RW7 for V10-V35. An absolute rectum V50 improvement5% was seen for the RB in 5 of 15 cases, for a benefit of 9.2% +/- 2.3% compared with 2.4% +/- 1.3% for the remaining 10 cases (p0.001). Similar benefit was seen for the rectal wall. No benefit was seen for dosesor =70 gray equivalents for the rectum, RW, or RW7. No benefit ofor =1% was seen with an RB in 46% for the rectum V70 and in 40% for the rectal wall V70.Rectum and rectal wall doses with proton radiation were low whether using water or an RB. Selected patients will have a small but significant advantage with an RB; however, water alone was well tolerated and will be an alternative for most patients. |
| Databáze: | OpenAIRE |
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