Running-Induced Systemic Cathepsin B Secretion Is Associated with Memory Function

Autor: Julie A. Mattison, Nigel H. Greig, Hyo Youl Moon, Henriette van Praag, Susan T. Lubejko, Nirnath Sah, Galit Benoni, David Berron, Benjamin Becker, Emma Janke, Emrah Düzel, Andreas Becke
Rok vydání: 2016
Předmět:
Doublecortin Domain Proteins
Male
0301 basic medicine
Aging
blood [Cathepsin B]
Physiology
metabolism [Neuropeptides]
physiology [Hippocampus]
Hippocampus
Hippocampal formation
Cathepsin B
Running
Cognition
physiology [Running]
0302 clinical medicine
Neurotrophic factors
Neurons
Mice
Knockout
Behavior
Animal
biology
Neurogenesis
physiology [Aging]
genetics [Cathepsin B]
metabolism [Brain-Derived Neurotrophic Factor]
metabolism [Neurons]
metabolism [Cathepsin B]
Female
Microtubule-Associated Proteins
Adult
medicine.medical_specialty
Doublecortin Protein
Motor Activity
Young Adult
03 medical and health sciences
Memory
ddc:570
Physical Conditioning
Animal
Internal medicine
medicine
Animals
Humans
Progenitor cell
physiology [Memory]
Molecular Biology
Brain-derived neurotrophic factor
Brain-Derived Neurotrophic Factor
Neuropeptides
Reproducibility of Results
metabolism [Microtubule-Associated Proteins]
Cell Biology
Macaca mulatta
Doublecortin
Mice
Inbred C57BL
Affect
030104 developmental biology
Endocrinology
Immunology
Exercise Test
biology.protein
Sedentary Behavior
030217 neurology & neurosurgery
Zdroj: Cell metabolism 24(2), 332-340 (2016). doi:10.1016/j.cmet.2016.05.025
ISSN: 1550-4131
DOI: 10.1016/j.cmet.2016.05.025
Popis: Peripheral processes that mediate beneficial effects of exercise on the brain remain sparsely explored. Here, we show that a muscle secretory factor, cathepsin B (CTSB) protein, is important for the cognitive and neurogenic benefits of running. Proteomic analysis revealed elevated levels of CTSB in conditioned medium derived from skeletal muscle cell cultures treated with AMP-kinase agonist AICAR. Consistently, running increased CTSB levels in mouse gastrocnemius muscle and plasma. Furthermore, recombinant CTSB application enhanced expression of brain-derived neurotrophic factor (BDNF) and doublecortin (DCX) in adult hippocampal progenitor cells through a mechanism dependent on the multifunctional protein P11. In vivo, in CTSB knockout (KO) mice, running did not enhance adult hippocampal neurogenesis and spatial memory function. Interestingly, in Rhesus monkeys and humans, treadmill exercise elevated CTSB in plasma. In humans, changes in CTSB levels correlated with fitness and hippocampus-dependent memory function. Our findings suggest CTSB as a mediator of effects of exercise on cognition.
Databáze: OpenAIRE
Externí odkaz: