Antioxidant and anticancer properties of leaves and seed cones from European yew (Taxus baccata L.)
| Autor: | Milena Ćurčić Milutinović, Vladimir Mihailovic, Snežana Marković, Danijela Cvetkovic, Milan Stanković, Marko Cvetkovic, Marina Topuzovic |
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| Rok vydání: | 2015 |
| Předmět: |
chemistry.chemical_classification
Antioxidant Taxus baccata L biology Traditional medicine medicine.medical_treatment Flavonoid apoptosis antioxidant activity biology.organism_classification General Biochemistry Genetics and Molecular Biology lcsh:Biology (General) chemistry Taxus Apoptosis Cell culture cytotoxity Botany Ic50 values medicine Potential source Taxaceae General Agricultural and Biological Sciences lcsh:QH301-705.5 |
| Zdroj: | Archives of Biological Sciences, Vol 67, Iss 2, Pp 525-534 (2015) |
| ISSN: | 1821-4339 0354-4664 |
| Popis: | Plant extracts of the leaves and seed cones of European yew Taxus baccata L. (Taxaceae) were analyzed for total phenolic content, flavonoid concentrations, antioxidant and anticancer properties (cytotoxic and proapoptotic activity). The total phenolic content ranged between 8.23 and 210.01 mg Ga/g, with the IC50 values for antioxidant activity between 25.24 and 533.66 ?g/ml. The MTT test showed that the methanolic extract of leaves had better activity on HCT-116 cells than the extract of seed cones, with IC50 values of 14.3 for 24 h and 4.59 for 72 h. The MDA-MB-231 cell line displayed significantly lower sensitivity to both extracts as compared to the HCT-116 cell line. Microscopic examination indicated that the extracts induced apoptosis in both cell lines. These results suggest that T. baccata leaves and seed cones are a potential source of phenolic compounds, especially flavonoids, as natural antioxidant, cytotoxic and strong proapoptotic substances of high value. This article has been corrected. Link to the correction 10.2298/ABS161021105E |
| Databáze: | OpenAIRE |
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