Green Methodologies for Copper(I)-Catalyzed Azide-Alkyne Cycloadditions: A Comparative Study
| Autor: | Kevin Stewart, Breanna Tracey, Laura George, Loren J. Taylor, Allison Duensing, Andrew Outlaw, Clayton Hull-Crew, Marissa Trujillo, Allen M. Schoffstall |
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| Rok vydání: | 2019 |
| Předmět: |
Glycerol
Green chemistry 1H-1 2 3-triazole microwave heating Pharmaceutical Science chemistry.chemical_element Alkyne Catalysis Article Analytical Chemistry copper-catalyzed azide-alkyne cycloaddition (CuAAC) lcsh:QD241-441 chemistry.chemical_compound lcsh:Organic chemistry Drug Discovery fluorotriazole Physical and Theoretical Chemistry Microwaves chemistry.chemical_classification green chemistry Organic Chemistry Green Chemistry Technology Copper Combinatorial chemistry Cycloaddition solvent-free reaction chemistry Chemistry (miscellaneous) Alkynes Yield (chemistry) Click chemistry Molecular Medicine Click Chemistry Azide |
| Zdroj: | Molecules, Vol 24, Iss 5, p 973 (2019) Molecules Volume 24 Issue 5 |
| ISSN: | 1420-3049 |
| DOI: | 10.3390/molecules24050973 |
| Popis: | Successful copper(I)-catalyzed azide-alkyne cycloaddition (CuAAC) reactions may be achieved by several methods. In this paper, four synthetic protocols were performed for direct comparison of time required for the synthesis, yield, and purity of the 1H-1,2,3-triazole products. The methods with Cu(I) catalysts were conventional, microwave heating, solvent-free, and a method using glycerol solvent. The compounds synthesized in this paper were known non-fluorinated triazoles and new fluorinated triazoles. The results lead to the conclusion that the microwave method should be strongly considered for CuAAC syntheses. |
| Databáze: | OpenAIRE |
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