Skin sympathetic nerve activity precedes the onset and termination of paroxysmal atrial tachycardia and fibrillation
| Autor: | Anisiia Doytchinova, Keith C. Wright, Andrea Uradu, Shien-Fong Lin, Changyu Shen, Juyi Wan, Lan S. Chen, Peng Sheng Chen, Andrew Y. Lin, Thomas H. Everett |
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| Rok vydání: | 2017 |
| Předmět: |
Tachycardia
Male medicine.medical_specialty Sympathetic Nervous System Statistics as Topic Diagnostic Techniques Neurological 030204 cardiovascular system & hematology Sick sinus syndrome 03 medical and health sciences Electrocardiography 0302 clinical medicine Heart Rate Physiology (medical) Internal medicine Heart rate Atrial Fibrillation medicine Tachycardia Supraventricular Humans Aged Sinoatrial Node Skin Fibrillation medicine.diagnostic_test business.industry Sinoatrial node Atrial fibrillation Middle Aged medicine.disease Autonomic nervous system medicine.anatomical_structure Anesthesia Cardiology Female medicine.symptom Cardiology and Cardiovascular Medicine business 030217 neurology & neurosurgery |
| Zdroj: | Heart rhythm. 14(7) |
| ISSN: | 1556-3871 |
| Popis: | Skin sympathetic nerve activity (SKNA) is useful for estimating sympathetic tone in humans.The purpose of this study was to test the hypotheses that (1) increased SKNA is associated with the onset and termination of paroxysmal atrial tachycardia (AT) and atrial fibrillation (AF) and (2) sinoatrial node response to SKNA is reduced in patients with more frequent AT or AF episodes.SKNA and electrocardiogram were recorded in 11 patients (4 men and 7 women; average age 66 ± 10 years), including 3 patients with AT (11 ± 18 episodes per patient) and 8 patients with AF (24 ± 26 episodes per patient).The average SKNA (aSKNA) 10 seconds before AT onset was 1.07 ± 0.10 μV and 10 seconds after termination was 1.27 ± 0.10 μV; both were significantly (P = .032 and P.0001) higher than that during sinus rhythm (0.97 ± 0.09 μV). The aSKNA 10 seconds before AF onset was 1.34 ± 0.07 μV and 10 seconds after termination was 1.31 ± 0.07 μV; both were significantly (P .0001) higher than that during sinus rhythm (1.04 ± 0.07 μV). The aSKNA before onset (P.0001) and after termination (P = .0011) was higher in AF than in AT. The sinus rate correlated (P.0001) with aSKNA in each patient (average r = 0.74; 95% confidence interval 0.65-0.84). The r value in each patient negatively correlated with the number of AT and AF episodes (r = -0.6493; 95% confidence interval -0.8990 to -0.08073; P = .0306).Increased SKNA was observed both at the onset and termination of AT and AF. Patients with more frequent AT and AF episodes had a weak correlation between sinus rate and aSKNA, suggesting sinoatrial node remodeling by tachycardia. |
| Databáze: | OpenAIRE |
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