Circadian variation of metabotropic glutamate receptor 5 availability in the rat brain
| Autor: | David Elmenhorst, Franziska Wedekind, Tina Kroll, Simone Beer, Heinz H. Coenen, Angela Oskamp, Johannes Ermert, Kristina Mertens, Eva-Maria Elmenhorst, Andreas Bauer |
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| Rok vydání: | 2016 |
| Předmět: |
Male
0301 basic medicine Cingulate cortex Positron emission tomography medicine.medical_specialty Light Pyridines Receptor Metabotropic Glutamate 5 Cognitive Neuroscience Nucleus accumbens Biology Amygdala Rats Sprague-Dawley Random Allocation 03 medical and health sciences Behavioral Neuroscience 0302 clinical medicine Internal medicine Oximes mental disorders medicine Animals rat metabotropic glutamate receptor Circadian rhythm Chronobiology Metabotropic glutamate receptor 5 Glutamate receptor Brain General Medicine Circadian Rhythm Rats Sleep deprivation 030104 developmental biology medicine.anatomical_structure Endocrinology nervous system Positron-Emission Tomography medicine.symptom [11C]ABP688 Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Journal of Sleep Research. 25:754-761 |
| ISSN: | 0962-1105 |
| Popis: | The metabotrophic subtype 5 glutamate receptor (mGluR5) plays a critical role in synaptic plasticity besides its involvement in numerous neurological disorders, such as depression. As mGluR5 availability in humans is altered in sleep deprivation, we hypothesized that mGluR5 availability underlies a circadian variation. To investigate whether mGluR5 underlies potential circadian changes we measured its density in a randomized fashion at six different daytimes in 11 adult Sprague-Dawley rats. mGluR5 density was quantified by positron emission tomography (PET) using the radioactive ligand [11 C]ABP688. [11 C]ABP688 uptake was quantified in nine regions of interest with a reference tissue model. Significant differences in the binding potential (BPND ) and therefore mGluR5 availability between the different circadian times were found in cortex, cingulate cortex, amygdala, caudate putamen and nucleus accumbens. Further post-hoc statistical analysis (Tukey-Kramer test) of the different time-points revealed significant changes in BPND between 07:00 hours (start of light-on phase) and 15:00 hours (last time-point of the light-on phase) in the caudate putamen. This study shows that mGluR5 availability is increased during the light-on, or sleep phase, of rodents by approximately 10%. Given that altered mGluR5 densities play a role in psychiatric disorders, further investigation is warranted to evaluate their circadian involvement in mood changes in humans. |
| Databáze: | OpenAIRE |
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