Defective Dendritic Cell Function in HIV-Infected Patients Receiving Effective Highly Active Antiretroviral Therapy: Neutralization of IL-10 Production and Depletion of CD4+CD25+ T Cells Restore High Levels of HIV-Specific CD4+ T Cell Responses Induced by Dendritic Cells Generated in the Presence of IFN-α
| Autor: | Laurence Weiss, Albertine Aouba, Cédric Carbonneil, Vladimira Donkova-Petrini |
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| Rok vydání: | 2004 |
| Předmět: |
CD4-Positive T-Lymphocytes
T cell Immunology Antigen presentation Cell Culture Techniques HIV Core Protein p24 HIV Infections Cell Separation Biology Lymphocyte Activation Monocytes Interferon-gamma Interleukin 21 Immune system Antiretroviral Therapy Highly Active medicine Humans Immunology and Allergy Cytotoxic T cell IL-2 receptor Antigen Presentation Interferon-alpha Cell Differentiation Receptors Interleukin-2 Dendritic Cells Dendritic cell Coculture Techniques Interleukin-10 medicine.anatomical_structure Interleukin-4 CD8 |
| Zdroj: | The Journal of Immunology. 172:7832-7840 |
| ISSN: | 1550-6606 0022-1767 |
| DOI: | 10.4049/jimmunol.172.12.7832 |
| Popis: | We previously demonstrated that GM-CSF/IFN-α combination allowed the differentiation of monocytes from HIV-infected patients into dendritic cells (DCs) exhibiting high CD8+ T cell stimulating abilities. The present study was aimed at characterizing the ability of DCs generated in the presence of GM-CSF and IFN-α to induce CD4 T cell responses. DCs were generated from monocytes of HIV-infected patients in the presence of GM-CSF with either IFN-α (IFN-DCs) or IL-4 (IL-4-DCs) for 7 days. Eleven patients receiving highly active antiretroviral therapy and exhibiting CD4 cell counts above 400/mm3 and plasma HIV-RNA |
| Databáze: | OpenAIRE |
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