pH effect on stability and kinetics degradation of nitazoxanide in solution
| Autor: | Julia Medeiros Sorrentino, Andreas Sebastian Loureiro Mendez, Nadia Maria Volpato, Fábio de Souza Barbosa, Leonardo Capra Pezzi, Martin Steppe |
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| Rok vydání: | 2020 |
| Předmět: |
Nitazoxanide
Hydronium Degradation kinetics lcsh:Biotechnology Kinetics kinetic Catalytic effect lcsh:Chemistry chemistry.chemical_compound degradation products lcsh:TP248.13-248.65 nitazoxanide medicine Kinetic Sability Farmácia sability lcsh:QD1-999 chemistry Hydroxide Degradation (geology) Estabilidade de medicamentos Degradation products Degradation rate constant Nuclear chemistry medicine.drug |
| Zdroj: | Repositório Institucional da UFRGS Universidade Federal do Rio Grande do Sul (UFRGS) instacron:UFRGS Drug Analytical Research; v. 4, n. 1 (2020); 12-17 Drug Analytical Research, Vol 4, Iss 1, Pp 12-17 (2020) |
| ISSN: | 2527-2616 |
| Popis: | Stability studies correspond to a set of tests designed to assess changes in the quality of a given drug over time and under the influence of a number of factors. Among these factors, pH plays an important role, due to the catalytic effect that hydronium and hydroxide ions can play in several reactions. In the present study, the degradation kinetics of nitazoxanide was evaluated over a wide pH range, and the main degradation product generated was identified by LC-MS/MS. Nitazoxanide showed first-order degradation kinetics in the pH range of 0.01 to 10.0 showing greater stability between pH 1.0 and 4.0. The degradation rate constant calculated for these pH was 0.0885 x 10-2 min-1 and 0.0689 x 10-2 min-1, respectively. The highest degradation rate constant value was observed at pH 10.0 (0.7418 x 10-2 min-1) followed by pH 0.01 (0.5882 x 10-2 min-1). A major degradation product (DP-1) was observed in all conditions tested. Through LC-MS/MS analysis, DP-1 was identified as a product of nitazoxanide deacetylation. The effect of pH on the stability of nitazoxanide and the kinetic data obtained contribute to a better understanding of the intrinsic stability characteristics of nitazoxanide. |
| Databáze: | OpenAIRE |
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