Atypical features and systemic associations in extensive cases of Grover disease: A systematic review
| Autor: | Matthew S. Goldberg, Kanade Shinkai, Madeleine Gantz, Jubin Ryu, Daniel C. Butler, Timothy H. McCalmont |
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| Rok vydání: | 2017 |
| Předmět: |
Adult
Male medicine.medical_specialty Skin Neoplasms Population Transient acantholytic dermatosis Dermatology Disease Malignancy Risk Assessment Severity of Illness Index Immunocompromised Host 030207 dermatology & venereal diseases 03 medical and health sciences Age Distribution 0302 clinical medicine Severity of illness medicine Humans Sex Distribution Buttocks education education.field_of_study business.industry Incidence Incidence (epidemiology) Biopsy Needle Ichthyosis Middle Aged Prognosis medicine.disease Immunohistochemistry Surgery Acantholysis medicine.anatomical_structure 030220 oncology & carcinogenesis Scalp Female business |
| Zdroj: | Journal of the American Academy of Dermatology. 77:952-957.e1 |
| ISSN: | 0190-9622 |
| DOI: | 10.1016/j.jaad.2017.06.041 |
| Popis: | Background Grover disease is an acantholytic disorder that typically occurs on the trunk of older individuals, primarily white men, in association with heat and xerosis. Cases with extensive and/or atypical distributions have been reported. Objective To review the literature characterizing the population, morphology, associations, and disease course of extensive or atypical eruptions of Grover disease. Methods A systematic literature review identified 50 articles with 69 cases. Results Patient age ranged from 14 to 83 years (mean age, 56 ± 15), with 71% of patients being male and 29% female. Areas of involvement included the trunk (90%), upper and lower extremities (63% and 61%, respectively), face/scalp (28%), neck (21%), groin (11%), buttocks (8%), and axillae (6%). The most common associations included a history of malignancy (61%), recent chemotherapy (38%), and recent transplant (20%). Limitations Extensive cases with typical clinical morphology may not have been examined by biopsy or reported; thus, this review may have publication bias toward more severe or atypical presentations. Conclusions Greater variability exists among patients affected by extensive or atypical Grover disease than among those with typical disease. Malignancy is a common association, and there may be a role for immunosuppression in the pathogenesis of extensive or atypical Grover disease. |
| Databáze: | OpenAIRE |
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