| Popis: |
Supplementary Figure 1 shows the chemical structure of exemestane, androstenedione and testosterone, and responses (calcium mobilization or currents) evoked by androstenedione and other steroid hormones in cells that express the native or recombinant (including a mutated form) TRPA1 channel. Supplementary Figure 2 shows the inhibitory effect of the ROS scavenger, alpha lipoic acid, on the mechanical allodynia induced by intragastric administration of letrozole. Supplementary Figure 3 shows that the combination of per se ineffective doses of androstenedione, letrozole or H202 is able to evoke mechanical allodynia. Supplementary Figure 4 shows the ability of the TRPA1 antagonist, HC-030031, and TRPV1 antagonist, capsazepine, to modulate the responses (mechanical allodynia, grip strength reduction) evoked by buthionine sulfoximine and androstenedione. |
