Increased alloreactive and autoreactive antihuman leucocyte antigen antibodies associated with systemic lupus erythematosus and rheumatoid arthritis
| Autor: | Giovanna Cruz, Darrell J Triulzi, Lisa F. Barcellos, Lindsey A. Criswell, Michael P. Busch, Philip J. Norris, Joanne Nititham, Rachael P. Jackman |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
autoantibodies Immunology Human leukocyte antigen medicine.disease_cause 03 medical and health sciences Immunology and Inflammation Antigen Disease severity immune system diseases medicine rheumatoid arthritis (RA) skin and connective tissue diseases systemic lupus erythematosus (SLE) biology business.industry Autoantibody General Medicine Immune dysregulation medicine.disease alloantibodies 3. Good health human leukocyte antigen (HLA) 030104 developmental biology Rheumatoid arthritis biology.protein Antibody business Nephritis |
| Zdroj: | Lupus Science & Medicine |
| ISSN: | 2053-8790 |
| Popis: | ObjectivesRheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) disproportionately affect women during and following childbearing years. Antihuman leucocyte antigen (HLA) alloantibody responses are common in healthy parous women, and as these diseases are both linked with HLA and immune dysregulation, we sought to evaluate anti-HLA antibodies in RA and SLE.MethodsAnti-HLA antibodies were measured among parous SLE cases (n=224), parous RA cases (n=202) and healthy parous controls (n=239) and compared with each other as well as with nulliparous female and male controls. Antibody specificities were identified and compared against subject HLA types to determine autoreactivity versus alloreactivity. The association of anti-HLA antibodies with clinical outcomes was evaluated.ResultsLevels and frequencies of anti-HLA antibodies were significantly higher among parous females with SLE (52%) or RA (46%) compared with controls (26%), and anti-HLA antibodies were also found among nulliparous females and males with SLE and RA. Autoreactive anti-HLA antibodies were observed among SLE and RA antibody-positive subjects, but not healthy controls, with the highest frequency of autoreactive anti-HLA antibodies found in the SLE subjects. Higher levels of anti-HLA antibodies were associated with nephritis among the nulliparous SLE cases (pConclusionsBoth autoreactive and alloreactive anti-HLA antibodies were found at high levels in RA and SLE subjects. These occurred even in the absence of alloexposure, particularly among SLE subjects and may be linked with disease severity. |
| Databáze: | OpenAIRE |
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