Successful implementation of outpatient R ± DHAX (rituximab, dexamethasone, oxaliplatin, cytarabine) for select patients with lymphoma: a single-center experience
| Autor: | Anas Younes, Joy C. Jarrett, Anita Kumar, Tara A. Duggan, Alison J. Moskowitz, Megan H. Leary, Ariela Noy, Colette Owens, Lorenzo Falchi, Gottfried von Keudell, Michael J Buege, Brianne N. Dixon, Paul A. Hamlin, Phuong H. Dao, Matthew J. Matasar, Andrew D. Zelenetz, Terry K. Pak, Philip Caron, Audrey Hamilton |
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| Rok vydání: | 2021 |
| Předmět: |
Cancer Research
medicine.medical_specialty Lymphoma Hospital bed medicine.medical_treatment Single Center Dexamethasone Patient satisfaction Antineoplastic Combined Chemotherapy Protocols Outpatients medicine Humans Adverse effect Chemotherapy business.industry Cytarabine Hematology Oxaliplatin Oncology Emergency medicine Rituximab business medicine.drug |
| Zdroj: | Leukemia & Lymphoma. 63:876-884 |
| ISSN: | 1029-2403 1042-8194 |
| Popis: | R ± DHAX has been traditionally administered to inpatient due to the timing of chemotherapy administration and the perceived need for close monitoring of adverse effects. To administer R ± DHAX outpatient, a multidisciplinary task force created clinical and educational guidelines which were implemented through two phases: pilot and expansion. The pilot program determined the feasibility of transitioning R ± DHAX outpatient at a single infusion site. The expansion phase led to a service-wide implementation across all outpatient sites. A total of 40 patients were included, of which 23 patients completed all cycles, outpatient, 12 transitioned inpatient to outpatient administration, and 5 transitioned outpatient to inpatient administration. The success rate of outpatient R ± DHAX administration was 90% (36 patients successfully completed outpatient administration/40 total patients). No cytarabine-related cerebellar or ophthalmic toxicity was reported. Outpatient R ± DHAX saved 192 hospital days. R ± DHAX could be successfully administered outpatient with minimal safety concerns and reduced hospital bed utilization. |
| Databáze: | OpenAIRE |
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