Duraplasty in Traumatic Thoracic Spinal Cord Injury: Impact on Spinal Cord Hemodynamics, Tissue Metabolism, Histology, and Behavioral Recovery Using a Porcine Model

Autor:	Rishab Gupta, Femke Streijger, Aysha Allard Brown, Mypinder S. Sekhon, Allan Fong, Neda Manouchehri, Kyoung-Tae Kim, Seth Tigchelaar, Jenny Sun, Donald E. G. Griesdale, Kitty So, Brian K. Kwon, Katelyn Shortt, Ella Liu, Chris D Daly, Peter A. Cripton, Martin Keung, Elena B. Okon, Charlotte J. Morrison
Rok vydání:	2021
Předmět:	030506 rehabilitation Traumatic spinal cord injury Swine Hemodynamics Thoracic Vertebrae 03 medical and health sciences 0302 clinical medicine Medicine Animals Tissue metabolism Spinal cord injury Spinal Cord Injuries Behavior Animal business.industry food and beverages Histology Recovery of Function Plastic Surgery Procedures Spinal cord medicine.disease nervous system diseases Disease Models Animal medicine.anatomical_structure Anesthesia Female Neurology (clinical) Dura Mater Subarachnoid space 0305 other medical science business 030217 neurology & neurosurgery Thoracic spinal cord injury
Zdroj:	Journal of neurotrauma. 38(21)
ISSN:	1557-9042
Popis:	After acute traumatic spinal cord injury (SCI), the spinal cord can swell to fill the subarachnoid space and become compressed by the surrounding dura. In a porcine model of SCI, we performed a duraplasty to expand the subarachnoid space around the injured spinal cord and evaluated how this influenced acute intraparenchymal hemodynamic and metabolic responses, in addition to histological and behavioral recovery. Female Yucatan pigs underwent a T10 SCI, with or without duraplasty. Using microsensors implanted into the spinal cord parenchyma, changes in blood flow (ΔSCBF), oxygenation (ΔPO
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::062befb505019953e4488cf8c1d6a5df https://pubmed.ncbi.nlm.nih.gov/34011164 Zobrazit plný text záznamu