REPEATABILITY OF THE SUGAR ABSORPTION TEST, USING LACTULOSE AND MANNITOL, FOR MEASURING INTESTINAL PERMEABILITY FOR SUGARS
| Autor: | J. J. Uil, Cjj Mulder, H. S. A. Heymans, A. M. Mulder, R. M. Van Elburg, F. T. M. Kokke, W. G. M. van de Broek |
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| Přispěvatelé: | Other departments |
| Jazyk: | angličtina |
| Rok vydání: | 1995 |
| Předmět: |
Adult
Male Sucrose medicine.medical_specialty Pathology Adolescent Gastrointestinal Diseases Gastroenterology Lactulose Reference Values Internal medicine medicine Humans Mannitol Enteropathy Child Intestinal permeability business.industry Infant Newborn Infant Reproducibility of Results Repeatability Middle Aged medicine.disease Confidence interval Celiac Disease Intestinal Absorption Reference values Pediatrics Perinatology and Child Health Female Sugar absorption business medicine.drug |
| Zdroj: | Journal of pediatric gastroenterology and nutrition, 20(2), 184-188. Lippincott Williams and Wilkins |
| ISSN: | 0277-2116 |
| DOI: | 10.1097/00005176-199502000-00008 |
| Popis: | Differential sugar-absorption tests for measuring intestinal permeability for sugars have been studied in a variety of gastrointestinal diseases. Their use in general practice has been hampered by a lack of data on reference values and repeatability of the test and the laboratory assay. In this study, we determined the reference values of the sugar-absorption test, using lactulose and mannitol as probe molecules, for children and adults. The repeatability of the test is good; linear relationship: slope, 0.825 [95% confidence interval (CI), 0.571, 1.152); intercept, 0.005 (95% CI, -0.004, 0.010). The repeatability of the laboratory assay for the sugar-absorption test is excellent; linear relationship: slope, 1.014 (95% CI, 0.870, 1.094); intercept, 0.002 (95% CI, -0.005, 0.010). The validation of the sugar-absorption test makes the test useful as a simple, noninvasive, reliable intestinal permeability test for sugars, which can be of use for clinical practice. Taking possible interfering factors into account, the sugar-absorption test can be used as a diagnostic test for enteropathy of different etiologies and evaluation of therapeutic interventions in both children and adults. Studies with the sugar-absorption test may clarify the role of intestinal permeability in the pathophysiology of a variety of gastrointestinal diseases. |
| Databáze: | OpenAIRE |
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