| Autor: |
Maynard, Juliana, Sally-Ann Emmas, Francois-Xavier Blé, Barjat, Hervé, Lawrie, Emily, Hancox, Urs, Oakes, Deborah, Polanska, Urszula, Barry, Simon |
| Rok vydání: |
2016 |
| DOI: |
10.6084/m9.figshare.c.3696793_d2.v1 |
| Popis: |
A single dose of AZD8186 (50 mg/kg) results in only limited apoptotic cell death and upregulatedcellular stress in PTEN null models. Cleaved caspase-3 (apoptosis) and γH2AX Ser139 levels (DNA damage, stress response): A) 786-0 model; B) U87-MG model; C) BT474C model. Western blot data is shown for individual animals and geomeanindicated; n > 8/group. D). Example Western blots for each biomarker in each model without and with AZD8186 treatment. (PDF 166 kb) |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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