Aging erythrocyte membranes as biomimetic nanometer carriers of liver-targeting chromium poisoning treatment
| Autor: | Meiyan Yang, Bai Lv, Guobao Yang, Yongxue Guo, Hao Wang, Jingzhou Liu, Jinpeng Zheng, Chunsheng Gao, Qing Yao, Yang Yang |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Drug
Chromium Male liver-targeted media_common.quotation_subject Chemistry Pharmaceutical Antidotes Pharmaceutical Science chemistry.chemical_element Aging erythrocyte membranes RM1-950 Pharmacology Rats Sprague-Dawley Mice Random Allocation Metal poisoning In vivo Biomimetic Materials Detoxification medicine Animals Particle Size media_common chromium poisoning Drug Carriers Chemistry bionic nanocarrier Erythrocyte Membrane technology industry and agriculture General Medicine Rats Drug Liberation Membrane RAW 264.7 Cells Liver Dimercaptosuccinic acid Drug delivery dimercaptosuccinic acid Nanoparticles Therapeutics. Pharmacology Succimer medicine.drug Research Article |
| Zdroj: | Drug Delivery article-version (VoR) Version of Record Drug Delivery, Vol 28, Iss 1, Pp 1455-1465 (2021) |
| ISSN: | 1521-0464 1071-7544 |
| Popis: | Chromium poisoning has become one of the most common heavy metal poisoning occupational diseases with high morbidity and mortality. However, most antidotes detoxify the whole body and are highly toxic. To achieve hepato-targeted chromium poisoning detoxification, a novel hepato-targeted strategy was developed using aging erythrocyte membranes (AEMs) as biomimetic material coated with a dimercaptosuccinic acid (DMSA) nanostructured lipid carrier to construct a biomimetic nano-drug delivery system. The particle size, potential, drug loading, encapsulation rate, in vitro release, and stability of the nanoparticles (NPs) were characterized. Confocal microscopy and flow cytometry showed that the prepared NPs could be phagocytized by RAW264.7 macrophage cells. The efficacy of AEM-DMSA-NPs for targeted liver detoxification was evaluated by in vitro MTT analysis and an in vivo model of chromium poisoning. The results showed that the NPs could safely and efficiently achieve targeted liver chromium poisoning detoxification. All the results indicated that the biomimetic nano-drug delivery system mediated by aging erythrocyte membranes and containing DMSA nanoparticles could be used as a novel therapeutic drug delivery system potentially targeting liver detoxification. |
| Databáze: | OpenAIRE |
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