Efficacy of fleroxacin in experimental methicillin-resistant Staphylococcus aureus endocarditis
| Autor: | L M Albrecht, Glenn W. Kaatz, Susan M. Seo, S L Barriere, Michael J. Rybak |
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| Rok vydání: | 1989 |
| Předmět: |
Male
Staphylococcus aureus Fleroxacin medicine.drug_class Penicillin Resistance Antibiotics Microbial Sensitivity Tests Biology medicine.disease_cause Microbiology Methicillin Ciprofloxacin medicine Animals Endocarditis Pharmacology (medical) Antibacterial agent Pharmacology Drug Resistance Microbial Endocarditis Bacterial Staphylococcal Infections medicine.disease Methicillin-resistant Staphylococcus aureus Infectious Diseases Bacteremia Vancomycin Rabbits Research Article medicine.drug |
| Zdroj: | Antimicrobial Agents and Chemotherapy. 33:519-521 |
| ISSN: | 1098-6596 0066-4804 |
| DOI: | 10.1128/aac.33.4.519 |
| Popis: | The efficacy of fleroxacin versus that of vancomycin was assessed by using the rabbit model of methicillin-resistant Staphylococcus aureus endocarditis. Animals were treated with fleroxacin (30 mg/kg of body weight every 8 h) or vancomycin (17.5 mg/kg every 6 h) for 4 days. These antimicrobial agents were equally effective in clearing bacteremia, reducing bacterial counts in vegetations and tissues, and curing endocarditis. However, resistance to fleroxacin at fivefold the MIC arose in the test strain of S. aureus in 8% of animals that received the drug. We conclude that fleroxacin is as efficacious as vancomycin in this model of a serious systemic S. aureus infection, but modest resistance to fleroxacin may develop during therapy. |
| Databáze: | OpenAIRE |
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