Carpesium divaricatum Sieb. & Zucc. Revisited: Newly Identified Constituents from Aerial Parts of the Plant and Their Possible Contribution to the Biological Activity of the Plant
| Autor: | Barbara Michalak, Natalia Kłeczek, Janusz Malarz, Anna K. Kiss, Anna Stojakowska |
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| Rok vydání: | 2019 |
| Předmět: |
medicine.drug_class
12-oxo-phytodienoic acid Pharmaceutical Science Carpesium divaricatum caffeic acid derivatives 01 natural sciences Article Anti-inflammatory Analytical Chemistry lcsh:QD241-441 chemistry.chemical_compound lcsh:Organic chemistry Chlorogenic acid Functional food Drug Discovery Caffeic acid medicine Physical and Theoretical Chemistry anti-inflammatory Traditional medicine biology 010405 organic chemistry Chemistry Organic Chemistry food and beverages ROS Biological activity Asteraceae biology.organism_classification cytokines Terpenoid 0104 chemical sciences 010404 medicinal & biomolecular chemistry Chemistry (miscellaneous) Shoot Molecular Medicine |
| Zdroj: | Molecules, Vol 24, Iss 8, p 1614 (2019) Molecules |
| ISSN: | 1420-3049 |
| DOI: | 10.3390/molecules24081614 |
| Popis: | Carpesium divaricatum Sieb. & Zucc. has a long history of use as both a medicinal and a food plant. However, except for terpenoids, its chemical constituents have remained poorly investigated. The composition of hydroalcoholic extract from aerial parts of C. divaricatum was analyzed by HPLC-DAD-MSn, revealing the presence of numerous caffeic acid derivatives that were formerly unknown constituents of the plant. In all, 17 compounds, including commonly found chlorogenic acids and rarely occurring butyryl and methylbutyryl tricaffeoylhexaric acids, were tentatively identified. Fractionation of lipophilic extract from cultivated shoots led to the isolation of 12-oxo-phytodienoic acid (12-OPDA), which is a newly identified constituent of the plant. The compound, at concentrations of 0.5, 1.0, and 2.5 μM, significantly reduced IL-8, IL-1β, TNFα, and CCL2 excretion by lipopolysaccharide (LPS)-stimulated human neutrophils. Reactive oxygen species (ROS) production induced by f-MLP was also significantly diminished in the neutrophils pretreated by 12-OPDA. The newly identified constituents of the plant seem to be partly responsible for its pharmacological activity and elevate the value of C. divaricatum as a potential functional food. |
| Databáze: | OpenAIRE |
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